giant cell


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gi·ant cell

a cell of large size, often with many nuclei.
Any markedly enlarged cell seen in benign or malignant lesions; while giant cells are highly nonspecific, their presence in the proper setting supports the diagnosis of certain diseases; the epithelioid giant cells of Langhans and Touton are associated with infections and other ‘benign’ processes—e.g., sarcoidosis—have abundant cytoplasm and a rim or clutch of enlarged histiocyte-like nuclei; giant cells in tumours are less inhibited by rules of cytologic etiquette and are anointed with adjectival modifiers—e.g., bizarre, monster, osteoclastoma-like, Reed-Sternberg; the cell may be markedly enlarged and mitotically active

giant cell

Any markedly enlarged cell seen in benign or malignant lesions; although GCs are highly nonspecific, their presence in the proper setting supports the diagnosis of certain diseases; the epithelioid GCs of Langerhans and Touton are associated with infections and other 'benign' processes–eg, sarcoidosis, have abundant cytoplasm and a rim or clutch of enlarged histiocyte-like nuclei; GCs in tumors are less inhibited by rules of cytologic etiquette and are anointed with adjectival modifiers–eg, bizarre, monster, osteoclastoma-like, Reed-Sternberg; the cell may be markedly enlarged and mitotically active.

gi·ant cell

(jī'ănt sel)
A cell of large size, often with many nuclei.

giant cell

A large multinucleate cell formed from the fusion of many MACROPHAGES. Giant cells are often a feature of granulomas.

gi·ant cell

(jī'ănt sel)
A cell of large size, often with many nuclei.
References in periodicals archive ?
Endometrial giant cell carcinoma: A case series and review of the spectrum of endometrial neoplasms containing giant cells.
Also no significant difference could be observed in the mean number of giant cells between group A-I and B-I.
Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone.
Histologically, giant cell reparative granuloma (GCG) looks like GCT.
Burt, "Post-infantile giant cell hepatitis: Histological and immunohistochemical study," Journal of Clinical Pathology, vol.
In a recent case report, recurrence of colon cancer was suspected after a suspicious lesion appeared on CT and PET scans, requiring exploratory laparotomy; a giant cell granuloma had developed around mesh used for prior abdominal hernia repair, demonstrating the ability of these lesions to mimic cancer and unavoidable surgical intervention [4].
Permanent histologic sections show a cellular neoplasm composed of large, epithelioid cells, with numerous multinucleated giant cells (Figure 3).
Seeger et al., "Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study," The Lancet Oncology, vol.
There are no detailed reports in the literature regarding the management of multiply recurrent giant cell tumor of the first metatarsal.
[13] reported four cases of cryptococcal infection (three meningitis) in patients whose immunosuppression was related to chronic lymphocytic leukemia, giant cell temporal arteritis, gastric neoplasm and lupus, respectively.