giant cell


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gi·ant cell

a cell of large size, often with many nuclei.

giant cell

[jī′ənt]
Etymology: L, gigas, huge, cella, storeroom
an abnormally large tissue cell that often contains more than one nucleus and may appear as a merger of several normal cells.
Any markedly enlarged cell seen in benign or malignant lesions; while giant cells are highly nonspecific, their presence in the proper setting supports the diagnosis of certain diseases; the epithelioid giant cells of Langhans and Touton are associated with infections and other ‘benign’ processes—e.g., sarcoidosis—have abundant cytoplasm and a rim or clutch of enlarged histiocyte-like nuclei; giant cells in tumours are less inhibited by rules of cytologic etiquette and are anointed with adjectival modifiers—e.g., bizarre, monster, osteoclastoma-like, Reed-Sternberg; the cell may be markedly enlarged and mitotically active

giant cell

Any markedly enlarged cell seen in benign or malignant lesions; although GCs are highly nonspecific, their presence in the proper setting supports the diagnosis of certain diseases; the epithelioid GCs of Langerhans and Touton are associated with infections and other 'benign' processes–eg, sarcoidosis, have abundant cytoplasm and a rim or clutch of enlarged histiocyte-like nuclei; GCs in tumors are less inhibited by rules of cytologic etiquette and are anointed with adjectival modifiers–eg, bizarre, monster, osteoclastoma-like, Reed-Sternberg; the cell may be markedly enlarged and mitotically active.

gi·ant cell

(jī'ănt sel)
A cell of large size, often with many nuclei.

giant cell

A large multinucleate cell formed from the fusion of many MACROPHAGES. Giant cells are often a feature of granulomas.

gi·ant cell

(jī'ănt sel)
A cell of large size, often with many nuclei.

giant cell,

n an abnormally large tissue cell. It often contains more than one nucleus and may appear as a merger of several normal cells.

giant cell

1. very large cells in normal tissue, e.g. megakaryocytes in bone marrow.
2. multinucleate macrophages found around foreign bodies and in granulomas. Three variants of multinucleated giant cells are recognized—Langhans, Touton and foreign body. Differentiation is based on the distribution of their nuclei.

giant cell epulis
peripheral giant cell granulomas appearing as bright red, smooth gingival masses in cats and dogs; includes hyperplastic epithelium and many giant cells in densely cellular stroma.
extraskeletal giant cell tumor
see malignant fibrous histiocytoma.
epidermal multinucleated giant cell
found in viral infections and chronic, pruritic dermatoses characterized by epidermal hyperplasia or dyskeratosis.
References in periodicals archive ?
Giant cell arteritis: a review of classification, pathophysiology, geoepidemiology and treatment.
High-speed burring with and without the use of surgical adjuvants in the intralesional management of giant cell tumor of bone: A systematic review and meta-analysis.
Giant cell arteritis of the breast may go unrecognized clinically for several reasons.
Primary hyperparathyroidism presented as central giant cell granuloma of jaw bones.
Giant cell tumor of the extremity: A review of 349 cases from a single institution.
Microscopical examination showed sheets of round to oval mononuclear cells with bland chromatin and conspicuous nucleoli uniformly interspersed with numerous osteoclast-like giant cells with nuclei similar to that of the mononuclear cells confirming the histopathological diagnosis of giant cell tumor [Figure 3].
Standard sections revealed a cellular process including giant cells and mononuclear stromal cells within a collagenous matrix (Figure 3(a)).
As the lesion progressed, it became apparent that the radiographic and MRI features of the lesion are suggestive of giant cell tumor of bone.
Giant cell tumour of soft tissue (GCT-ST) clinically presents as painless, firm, well-defined mass without any fixity to underlying structure.
Neoplastic multinucleated giant cells are common, and reactive foreign-body-type giant cells may also be seen (figure 2).
Many of these lesions can be identified as specific entities on the basis of their histopathological features and are divided into irritational fibroma, epulis fissuratum, squamous papilloma, giant cell fibroma, pyogenic granuloma and peripheral giant cell granuloma.