ghrelin


Also found in: Dictionary, Thesaurus, Wikipedia.
Related to ghrelin: PYY

ghrel·in

(grel'in),
A naturally occurring 28-amino acid gut-brain growth hormone releasing peptide (GHRP) that is expressed mainly in the stomach and possibly in the hypothalamus. Fasting and hypoglycemia increase ghrelin levels and circulating ghrelin levels are decreased in chronic obesity, following acute caloric intake and in states of positive energy balance. Acute administration of ghrelin to humans induces a feeling of hunger. Ghrelin binds to ghrelin-receptors in the anterior pituitary and possibly in the mediobasal and mediolateral hypothalamus to stimulate growth hormone release and to regulate energy homeostasis. Serum levels of ghrelin are measurably higher in patients who have lost weight through dietary measures.
[growth hormone release + -in]

ghrelin

(grĕl′ən)
n.
A hormone that is secreted by cells in the stomach and promotes hunger before an expected meal, decreases in amount after eating, and promotes secretion of growth hormone.

ghrel·in

(grel'in)
A peptide hormone secreted by endocrine cells in the gastrointestinal tract. Acts as a growth hormone secretagogue and as an orexigenic agent mediated by the hypothalamic hormones neuropeptide Y (NPY) and agouti growth-related peptide (AGRP).
[growth hormone release + -in]

ghrelin

A 28-amino acid peptide hormone that stimulates release of growth hormone from the anterior pituitary and has significant effects on appetite and energy balance. The main source of ghrelin is the epithelial cells of the fundus of the empty stomach. Recent studies have shown that, in mice, the hormone also interacts with the hippocampus and appears to improve memory and cognitive function.

Ghrelin

A recently discovered peptide hormone secreted by cells in the lining of the stomach. Ghrelin is important in appetite regulation and maintaining the body's energy balance.
Mentioned in: Obesity
References in periodicals archive ?
Inadequate sleep is associated with greater hunger from increased ghrelin and decreased levels of leptin, which is a hormone that suppresses appetite and signals the brain to stop eating.
In the control group, positive correlations were determined between the body weight and leptin, leptin and ghrelin, leptin and TSH, TSH and leptin, TSH and ghrelin, TSH and testosterone, and the growth hormone and ghrelin (P<0.
Results: The fall in leukocyte count of chemotherapy and ghrelin group on day 7 was less as compared to the chemotherapy-only treated group and chemotherapy, ghrelin and growth hormone releasing hormone antagonist treated group (p<0.
While ghrelin tends to be fast-acting, leptin is more important for long-term energy regulation.
The report provides a snapshot of the global therapeutic landscape for Growth Hormone Secretagogue Receptor Type 1 (GHS-R or GH-Releasing Peptide Receptor or GHRP or Ghrelin Receptor or GHSR)
Additionally, an attempt was made to examine whether the possible effects of ghrelin on sexual behavior and LH beta-subunit gene expression depends on an interaction with GHSR-1a (5-7).
According to the company, Entyce, a ghrelin agonist, is a new chemical entity and a first-of-its-kind therapeutic to treat inappetence in dogs.
The first animal experiments designed to reduce ghrelin production and cause reduced appetite were first reported in 2007 and 2008 by Arvind Arepally, MD, at Johns Hopkins University.
Thus, we aimed to explore whether ghrelin is able to protect INS-1 cells from dexamethasone-induced cell apoptosis and determine its mechanism of action.
Authors proposed that the adult RS leads to increased ghrelin levels following activation of the sympathetic nerves.
For a time, the ghrelin levels following surgery will not even reach the hunger level of a nondieting person.