gestrinone


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gestrinone

A testosterone-like drug that interferes with the release of GONADOTROPHIC HORMONES and can be used in women to treat ENDOMETRIOSIS. A brand name is Dimetriose.
References in periodicals archive ?
Objective: To evaluate the clinical therapeutic effects of mifepristone combined with gestrinone on patients with endometriosis.
Exogenous: 1-androstendiol, 1-androstendione, bolandiol, bolasterone, boldenone, boldione, calusterone, clostebol, danazol, dehydrochlormethyltestosterone, desoxymethyltestosterone, drostanolone, ethylestrenol, fluoxymesterone, formebolone, furazabol, gestrinone, 4-hydroxytestosterone, mestanolone, mesterolone, metenolone, methandienone, methandriol, methasterone, methyldienolone, methyl-1-testosterone, methylnortestosterone, methyltrienolone, methyltestosterone, mibolerone, nandrolone, 19-norandrostenedione, norboletone, norclostebol, norethandrolone, oxabolone, oxandrolone, oxymesterone, oxymetholone, prostanozol, quinbolone, tanozolol, stenbolone, 1-testosterone, tetrahydrogestrinone, trenbolone
13) One Chinese trial found that the anti-progestin gestrinone was as effective as 10 mg mifepristone.
Fedele and co-workers (46) were the first to compare the clinical effects of gestrinone and danazol, observing a significant decrease of pain-related symptoms (dysmenorrhoea, pelvic pain, deep dyspareunia) in both groups, without any significant difference.
The findings from two trials showed that post-surgical administration of herbal medicine may have comparable benefits to gestrinone but with fewer side effects, oral herbal medicine may have a better overall treatment effect than danazol, and it may be more effective in relieving dysmenorrheal and shrinking adnexal masses when used in conjunction with an herbal enema.
However, gestrinone seemed to shorten women's menstrual cycle (7% of gestrinone users had their period seven days before it was expected, compared with 3% of mifepristone users), whereas mifepristone seemed to lengthen their menstrual cycle (20% of mifepristone users had their period 3-7 days after it was expected, compared with 14% of gestrinone users).
Gestrinone is a 19-notestosterone derivative with antiprogestinic, anti-oestrogenic and androgenic effects.
Discovery, biosynthesis, and structure elucidation of metabolites of a doping agent and a direct analogue, tetrahydrogestrinone and gestrinone, using human hepatocytes.
In one trial, Chinese herbal medicine provided symptomatic relief comparable to that provided by the hormonal drug gestrinone, but with fewer side effects.
The list, drawn up by the World Anti-Doping Agency, included the substances gestrinone and danazol.
THG, banned because it is related to the steroid gestrinone, was discovered by scientists at the Olympic Analytical Laboratory in Los Angeles last year.

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