gestational trophoblastic disease


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hy·da·tid·i·form mole

, hydatid mole [MIM*231090]
a vesicular or polycystic mass resulting from the proliferation of the trophoblast, with hydropic degeneration and avascularity of the chorionic villi; the abnormal tissue typically results from expression of paternally derived chromosomes and a loss of maternal chromosomes.

gestational trophoblastic disease

A generic term for a group of pregnancy-related disorders that arise from the trophoblast and clinically range from banal (e.g., hydatidiform mole) to aggressively malignant (e.g., choriocarcinoma).

Gestational trophoblastic disease
Hydatidiform mole
• Complete mole
• Partial mole
• Invasive mole
Placental site trophoblastic tumour
Epithelioid trophoblastic tumour
Choriocarcinoma

gestational trophoblastic disease

Gynecology A general term for the proliferative processes arising in trophoblastic tissue in ♀ of child-bearing age Types Gestational trophoblastic tumor/neoplasia, molar pregnancy, choriocarcinoma. See Choriocarcinoma, Mole, Trophoblastic tumor.

Gestational trophoblastic disease

A rare, aggressive, malignant, often metastatic (spreading to other organs) cancer in women of childbearing age in which cancer cells grow in the tissues that are formed in the uterus after conception
References in periodicals archive ?
Gestational trophoblastic diseases are proliferative disorders of the placental trophoblast, of either nonneoplastic (hydatidiform moles) or true neoplastic (gestational trophoblastic tumors) proliferation.
Gestational trophoblastic disease: psychological aspects and fertility issues.
Gestational trophoblastic diseases are a spectrum of related disorders which consist of benign trophoblastic lesions, premalignant hydatidiform moles, and neopla-stic diseases.1 The incidence of molar pregnancy is in-creasing in South East Asia ranges from 3.2 9.9 / 1000 gestation.2 The incidence of molar pregnancy de-monstrated marked geographic and ethnic differences.
Dickey, "Gestational trophoblastic disease: radiologic-pathologic correlation," Radiographics, vol.
Cardoza, "Sonographic and Doppler imaging in the diagnosis and treatment of gestational trophoblastic disease: a 12-year experience," Journal of Ultrasound in Medicine, vol.
Gestational Trophoblastic Disease. London: Chapman and Hall, 1997; 27- 42.
The use of total hCG measurement in gestational trophoblastic diseases is an example of a tumor marker with 100% sensitivity and 100% specificity for trophoblast-tissue mass, with the amount of tumor tissue or mole being directly proportional to the circulating concentration of total hCG.
Persistent gestational trophoblastic disease is normally treated with single agent chemotherapy with methotrexate.
Chapters cover topics such as vulvar dystrophies, vulvar intraepithelial neoplasia and cancer, endometrial hyperplasia and cancer, adnexal mass, ovarian tumors of low malignant potential, and gestational trophoblastic disease. Clarke-Pearson and Soper are professors of obstetrics and gynecology at the University of North Carolina.
True (A) or false (B)--click on the correct answer: The incidence of gestational trophoblastic disease in women who conceive around the time of their menopause is considerably higher than in younger women.
Patients with gestational trophoblastic disease secrete intact hCG, hCG[beta], nicked hCG and hCG[beta], and in some cases hCG devoid of the carboxy-terminal portion of the hCG[beta] subunit and hCGh.