gnotobiotic

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gno·to·bi·ot·ic

(nō'tō-bī-ot'ik),

Denoting germ-free or formerly germ-free organisms in which the composition of any associated microbial flora, if present, is fully defined.

[see gnotobiota]

Farlex Partner Medical Dictionary © Farlex 2012

gnotobiotic

Biology
adjective Referring to a system to which only preselected components, organisms and nutrients are introduced. Gnotobiotic organisms are either experimental models (e.g., mice with naïve immune systems), or “experiments of nature”, in which the natural immune defence is grossly defective (e.g., severe combined immune deficiency); prolonged survival of the host requires complete avoidance of exposure to pathogens.

gno·to·bi·ot·ic

(nō'tō-bī-ot'ik)

Denoting germ-free or formerly germ-free organisms in which the composition of any associated microbial flora, if present, is fully defined.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

gnotobiotic

literally ‘known life’; typically referring to an environment or animal that is essentially germ-(microorganism-) free, or one in which the microbial flora present is known, usually because it has been deliberately introduced.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

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This work involved a series of complicated experiments to demonstrate that mice reared germ-free (GF) are protected from diet-induced obesity and are unable to absorb fat compared to conventionally-raised mice, also known as specific pathogen free (SPF) mice.

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Results demonstrated that both germ-free mice lacking a microbiome and antibiotics-treated mice with a dysbiotic microbiome, failed to mount an effective anti-tumor response following treatment with an anti-PD-1 checkpoint inhibitor.

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Moreover, these malevolent dili ingon nato (Cebuano for the 'not-like-us') are dangerous because, like germs, you can't see them, so for good measure as we try to create a germ-free environment, we use deodorants and air fresheners.

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They said that we should endeavour individually and collectively to confront this challenge and make our lives germ-free and avoid diseases

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To date, the majority of research in this field has been done in germ-free mice; altering or disrupting their microbiome has been demonstrated to mimic human depression, anxiety, and autism.