germ line


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Related to germ line: germ layer, Germline mutation

germ line

a collection of haploid cells derived from the specialized cells of the primitive gonad.

germ line

genetic material in a cell lineage that is passed down through the gametes before it is modified by somatic recombination or maturation.

germ line

(jĕrm līn)
A collection of haploid cells derived from the specialized cells of the primitive gonad.

germ line

1. The lineage of cells leading to the contemporary GERM CELLS.
2. Often used loosely to refer to the cells of the ovary and testes that give rise, respectively, to the ova and spermatozoa, and to the ova and spermatozoa themselves.

germ line

a group of cells that give rise to the GONADS, becoming differentiated from the ‘somatic’ cells early in embryonic development. Only germ-line cells have the potential to undergo MEIOSIS, and a MUTATION event in these cells may well be transmitted to the offspring, unlike genetic change in somatic cells (see SOMATIC MUTATION).

germ

1. old-fashioned and lay term for a pathogenic microorganism.
2. living substance capable of developing into an organ, part or organism as a whole; a primordium. Commonly used to refer to the embryos of wheat grains which are removed during milling and sold separately as wheat germ.
germ cell
direct descendants of the primordial cells which originate from the yolk sac endoderm and migrate to the gonadal ridges of the embryo, where they give rise to either ova or spermatozoa. Called also gonocytes, sex cells.
germ cell tumor
a rare tumor in dogs, similar to more common lesions in humans. Similar to pituitary adenomas in distribution and cellular characteristics.
germ line
the genetic material as it is transferred via the gametes, before being modified by somatic recombination or mutation.
germ line cells
gametes.
germ line transmission
a mode of transmission, particularly of retroviruses, whereby the genome of the virus is integrated into the chromosomal DNA and transmitted via gametes to offspring.
germ plasma evaluation program
a planned investigative, large scale breeding program aimed at accumulating comparative information on the relative performance of various breeds and crossbreeds of agricultural animals.
germ theory
1. all organisms are developed from a cell.
2. infectious diseases are of microbial origin.
germ tube
a tube-like structure that develops during the growth of some fungi and becomes a hypha; a feature of the yeast, Candida albicans.
wheat germ
see wheat germ.
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References in periodicals archive ?
Oyster vasa-like gene as a marker of the germ line cell development in Crassostrea gigas.
Distribution and migration of immature germ cells in the pearl oyster Pinctada fucata with the expression pattern of the vasa ortholog by in situ hybridization
With regard to South African legislation, [25] alteration of germ line genetics and cloning other than reproducing human beings is not mentioned, and it is not clear whether the lack of information on these techniques implies that they are not prohibited.
Mitochondrial transfer: ethical, legal and social implications in assisted reproduction
The importance of identifying individuals with germ line mutations lies in enrolling these individuals into screening programmes to allow for polyp and early cancer detection.
Colorectal cancer is common and survival is strongly related to the stage of the disease at diagnosis
Based on our findings, we can conclude that sorting of stem cells derived germ line cells based on promoter of specific gene could be high and efficiently safe method for cell therapy.
Generation of in-vitro spermatogonial stem cells following genetic manipulation of primordial germ-like cells
West: Once we knew it was telomerase that was maintaining the germ line, it occurred to me that we might be able to isolate germ line cells from human embryos and just propagate them in a laboratory dish.
Immortal stem cells for anti-aging therapies: an interview with Michael D. West, PhD
Effects of chemicals on the germ lines of male mice were tested in a study designed to replicate pesticide use.
Epigenetic effects of diet on fruit fly lifespan: an investigation to teach epigenetics to biology students
However, little is known about the relevance of the germ-line mutations of CHEK2 in the risk for developing leukemia and whether the germ line 1100delC CHEK2 sequence variant confers higher risk of leukemia, especially for treatment-related leukemia (TRL) and MDS.
Locked nucleic acid-enhanced detection of 1100delC*CHEK2 germ-line mutation in Spanish patients with hematologic malignancies
Biocons have made the permissibility of direct intervention in the germ line a touchstone issue, and many transhumanists have followed them in framing the debate in these terms.
The new perfectionism: introduction
Currently, strategies for gene therapy that would result in the alteration of the germ line are not considered appropriate.
Embryos and ethics
The DNA that succeeds in traveling from the egg and sperm of one generation to the egg and sperm of the next is called the germ line of the species.
DNA and Neshamah: locating the soul in an age of molecular medicine
Analysis of Testes and Semen from Rabbits Treated by Intravenous Injection with a Retroviral Vector Encoding the Human Factor VIII Gene: No Evidence of Germ Line Transduction," Human Gene Therapy 11, no.
The risks of germline gene transfer. (another voice)
46) Along with the identification of traits ascribed to specific genes at specific locations, it is the hope that somatic and germ line therapies will be discovered that will establish genetic links to disease and afford medicine the means, by adjusting and altering genetic protein structures, to ease the suffering inflicted by diseases like Cystic Fibrosis, Parkinson's, and cancer.
Human cloning and genetic engineering: the case for proceeding cautiously

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