germ line


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Related to germ line: germ layer, Germline mutation

germ line

a collection of haploid cells derived from the specialized cells of the primitive gonad.

germ line

(jĕrm līn)
A collection of haploid cells derived from the specialized cells of the primitive gonad.

germ line

1. The lineage of cells leading to the contemporary GERM CELLS.
2. Often used loosely to refer to the cells of the ovary and testes that give rise, respectively, to the ova and spermatozoa, and to the ova and spermatozoa themselves.

germ line

a group of cells that give rise to the GONADS, becoming differentiated from the ‘somatic’ cells early in embryonic development. Only germ-line cells have the potential to undergo MEIOSIS, and a MUTATION event in these cells may well be transmitted to the offspring, unlike genetic change in somatic cells (see SOMATIC MUTATION).
References in periodicals archive ?
It is important to stop the jumping genes in the germ line because DNA in those cells will be passed on to future generations.
Not only does germ line gene therapy not require the manipulation of normal embryos; it may not even demand the manipulation of abnormal embryos.
The NHA does not mention alteration of germ line genetics or reproductive embryo cloning.
But all these declarations were made before it was actually feasible to precisely engineer the germ line. Now, with CRISPR, it is possible.
In 2009 we proposed [1] a solution for the problem of "escaping germ line from aging" within the framework of a wide range of hypotheses based on the aging notion as a process of accumulation of genomic errors [24-27, 36-38].
In the niche are three kinds of cells: germ line stem cells, which divide to produce sperm; somatic cyst stem cells, which make a kind of cell that helps the sperm-producing cells out; and hub cells, which make signals that keep the other two kinds of cells going.
Two mitochondrial replacement therapy scenarios would result in genetic modification of an individual's germ line, and one of these involves human reproductive cloning.
elegans has an invariant cell lineage; however, unlike the 959 terminally differentiated somatic cells, the hermaphrodite germ line contains actively dividing and differentiating cells [10-12].
Researchers used a virus to generate transgenic animals - a foreign gene that has been deliberately inserted into the genome - on the male germ line.
Observable effects in the [F.sub.3] generation are thought to result from changes to the germ line, which is the succession of germ cell DNA that passes from one generation to the next.
Several particular problems are addressed including the moral status of an embryo, cloning for reproduction and germ line therapy, end of life decisions, and the possibility of conscious robots.