geranylgeranyl pyrophosphate


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ger·a·nyl·ger·a·nyl py·ro·phos·phate

(jer'a-nil-jer'a-nil pī'rō-fos'fāt),
A key intermediate in the biosynthesis of many terpenes; the key substrate for introducing the geranylgeranyl group into proteins.
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cDNA Forward primer Reverse primer HMGR 5-GAATGCAGAGAAAGGTGCAA-3 5-CACCACGTTCATGAGTTTCC-3 FPPS 5-GCACTGACATCCAGGACAAC-3 5-TAAGATCTGGCGCTGTTGAG-3 SQS 5-CAAGCAGGTCATCTCCAAGA-3 5-GCAGCCAAGAGCATGATAAA-3 GGPPS 5-TGGAACTTCATCAGGGACAA-3 5-CCTGTCTTCTGCAACACCAT-3 FNT-[beta] 5-TGGCAGTAATCCTGGAACTG-3 5-GAGCTCGCTGTGACTGTAGC-3 GGT-1[beta] 5-GCTAAATGGCCAGACAGTCA-3 5-CAAATCCCACTCTCCTCCAT-3 [beta]-actin 5-CTCCATCCTGGCCTCGCTGT-3 5-GCTGTCACCTTCACCGTT-3 HMGR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase; FPPS, farnesyl pyrophosphate synthase; SQS, squalene synthase; GGPPS, geranylgeranyl pyrophosphate synthase; FNT-[beta], farnesyltransferase-[beta]; GGT-1[beta], geranylgeranyltransferase-1[beta].
Cells were treated with mevastatin at 0-20 (Calbiochem, San Diego, CA) with or without geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP) (Sigma, St.
Human osteoblasts treated with substrates of cholesterol biosynthesis, which are downstream of HMG CoA reductase reaction (mevalonate, and geranylgeranyl pyrophosphate), reversed atorvastatin-induced enhancement of OPG production.