cDNA Forward primer Reverse primer HMGR 5-GAATGCAGAGAAAGGTGCAA-3 5-CACCACGTTCATGAGTTTCC-3 FPPS 5-GCACTGACATCCAGGACAAC-3 5-TAAGATCTGGCGCTGTTGAG-3 SQS 5-CAAGCAGGTCATCTCCAAGA-3 5-GCAGCCAAGAGCATGATAAA-3 GGPPS 5-TGGAACTTCATCAGGGACAA-3 5-CCTGTCTTCTGCAACACCAT-3 FNT-[beta] 5-TGGCAGTAATCCTGGAACTG-3 5-GAGCTCGCTGTGACTGTAGC-3 GGT-1[beta] 5-GCTAAATGGCCAGACAGTCA-3 5-CAAATCCCACTCTCCTCCAT-3 [beta]-actin 5-CTCCATCCTGGCCTCGCTGT-3 5-GCTGTCACCTTCACCGTT-3 HMGR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase; FPPS, farnesyl pyrophosphate synthase; SQS, squalene synthase; GGPPS,
geranylgeranyl pyrophosphate synthase; FNT-[beta], farnesyltransferase-[beta]; GGT-1[beta], geranylgeranyltransferase-1[beta].
Human osteoblasts treated with substrates of cholesterol biosynthesis, which are downstream of HMG CoA reductase reaction (mevalonate, and
geranylgeranyl pyrophosphate), reversed atorvastatin-induced enhancement of OPG production.