geranylgeranyl pyrophosphate

ger·a·nyl·ger·a·nyl py·ro·phos·phate

(jer'a-nil-jer'a-nil pī'rō-fos'fāt),

A key intermediate in the biosynthesis of many terpenes; the key substrate for introducing the geranylgeranyl group into proteins.

References in periodicals archive ?

cDNA Forward primer Reverse primer HMGR 5-GAATGCAGAGAAAGGTGCAA-3 5-CACCACGTTCATGAGTTTCC-3 FPPS 5-GCACTGACATCCAGGACAAC-3 5-TAAGATCTGGCGCTGTTGAG-3 SQS 5-CAAGCAGGTCATCTCCAAGA-3 5-GCAGCCAAGAGCATGATAAA-3 GGPPS 5-TGGAACTTCATCAGGGACAA-3 5-CCTGTCTTCTGCAACACCAT-3 FNT-[beta] 5-TGGCAGTAATCCTGGAACTG-3 5-GAGCTCGCTGTGACTGTAGC-3 GGT-1[beta] 5-GCTAAATGGCCAGACAGTCA-3 5-CAAATCCCACTCTCCTCCAT-3 [beta]-actin 5-CTCCATCCTGGCCTCGCTGT-3 5-GCTGTCACCTTCACCGTT-3 HMGR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase; FPPS, farnesyl pyrophosphate synthase; SQS, squalene synthase; GGPPS, geranylgeranyl pyrophosphate synthase; FNT-[beta], farnesyltransferase-[beta]; GGT-1[beta], geranylgeranyltransferase-1[beta].

Alteration of mevalonate pathway in proliferated vascular smooth muscle from diabetic mice: possible role in high-glucose-induced atherogenic process

Cells were treated with mevastatin at 0-20 (Calbiochem, San Diego, CA) with or without geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP) (Sigma, St.

Increased expression of RhoA in epithelium and smooth muscle of obese mouse models: implications for isoprenoid control of airway smooth muscle and fibroblasts

Human osteoblasts treated with substrates of cholesterol biosynthesis, which are downstream of HMG CoA reductase reaction (mevalonate, and geranylgeranyl pyrophosphate), reversed atorvastatin-induced enhancement of OPG production.