In vivo studies and incorporation of radioactive compounds experiments revealed that geranyl pyrophosphate
is the precursor of iridoids [37-39].
In addition to the effects on cholesterol biosynthesis, statins regulate the synthesis of various other major products such as dolichol, geranyl pyrophosphate
, and farnesyl pyrophosphate.
Researchers have illustrated that geraniol can be synthesised by geraniol synthase from geranyl pyrophosphate
(GPP) [10,15], then by a dehydrogenase [10,19] or an oxidase [10,17] be converted to geranial.
The transient intermediate (10) undergoes an El elimination to generate a new carbon-carbon double bond and form geranyl pyrophosphate