gephyrin


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ge·phy·rin

(je-fir'in), [MIM*603930]
A protein in the ataxia telangiectasia mutation-related family, essential for glycine receptor clustering on neuronal membranes.
Farlex Partner Medical Dictionary © Farlex 2012

ge·phy·rin

(je-fir'in)
A protein in the ataxia telangiectasia mutation-related family, essential for glycine receptor clustering on neuronal membranes.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Consistent with this computational prediction, immunohistological analyses revealed significantly decreased numbers of [GABA.sub.A] receptor and gephyrin clusters in the granule cell layer of NL2 KOs, indicating a loss of synaptic [GABA.sub.A] receptors from the somata of granule cells.
(31) Gephyrin is a major scaffolding molecule of inhibitory postsynaptic specialization.
Very recently, long-term treatment with antimalarial drugs that target gephyrin (a protein that participates in GABAA-R transport to the membrane), or treatment with GABA, was shown to promote islet [alpha]-cell transdifferentiation into [beta]-cells [22, 23].
In transgenic (TG2576) and Swedish transgenic (TG-SwDI) mice, dihydromyricetin may reduce A[beta] peptide production and restore gephyrin levels, GABAergic transmission, and functional synapses, leading to improvement of clinical symptoms [63].
Burkarth N, Kriebel M, Kranz EU, Volkmer H, 2007, Neurofascin regulates the formation of gephyrin clusters and their subsequent translocation to the axon hillock of hippocampal neurons.
[39] Antibodies directed against gephyrin, a post-synaptic cytosolic vesicle protein, may also be produced.
Bechade, "Expression of glycine receptor a subunits and gephyrin in cultured spinal neurons," European Journal of Neuroscience, vol.
[120] A study by Chhatwal and colleagues, [121] found that gephyrin (which regulates GABAergic neurotransmission by clustering GABAA receptors at the synapse) is unregulated after extinction training but down-regulated after fear acquisition, confirming the role of GABAA receptors in both fear acquisition and extinction.