31)
Gephyrin is a major scaffolding molecule of inhibitory postsynaptic specialization.
Burkarth N, Kriebel M, Kranz EU, Volkmer H, 2007, Neurofascin regulates the formation of
gephyrin clusters and their subsequent translocation to the axon hillock of hippocampal neurons.
Splice-specific Functions of
Gephyrin in Molybdenum Cofactor Biosynthesis, Journal of Biological Chemistry 283 (25): 17370-9.
Regulation of synaptic strength involves lateral diffusion of GABAARs into and out of synapses, endocytic downregulation followed by either degradation or membrane re-insertion, and altering the size of
gephyrin clusters.
39] Antibodies directed against
gephyrin, a post-synaptic cytosolic vesicle protein, may also be produced.
120] A study by Chhatwal and colleagues, [121] found that
gephyrin (which regulates GABAergic neurotransmission by clustering GABAA receptors at the synapse) is unregulated after extinction training but down-regulated after fear acquisition, confirming the role of GABAA receptors in both fear acquisition and extinction.
Fast and reversible trapping of surface glycine receptors by
gephyrin.
