gentamicin


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Related to gentamicin: vancomycin

gentamicin

 [jen″tah-mi´sin]
an aminoglycosideantibiotic complex elaborated by bacteria of the genus Micromonospora, effective against many gram-negative bacteria, especially Pseudomonas species, as well as certain gram-positive bacteria, especially Staphylococcus aureus; used as the sulfate salt.

gen·ta·mi·cin

(jen'tă-mī'sin), Avoid the misspelling gentamycin.
A broad spectrum antibiotic of the aminoglycoside class, obtained from Micromonospora purpurea and M. echinospora, which inhibits the growth of both gram-positive and gram-negative bacteria; the sulfate salt is used medicinally.

gentamicin

(jĕn′tə-mī′sĭn)
n.
A broad-spectrum antibiotic derived from an actinomycete of the genus Micromonospora, used in its sulfate form to treat various infections.

gentamicin

Garamycin® Infectious disease A broad-spectrum aminoglycoside antibiotic obtained from Micromonospora purpurea Adverse effects Ototoxicity, nephrotoxicity Therapeutic range Peak 5-10 mg/L; trough < 2 mg/L Toxic range Peak > 10 mg/L; trough > 2 mg/L. See Aminoglycosides.

gen·ta·mi·cin

(jen'tă-mī'sin) Avoid the misspelling gentamycin.
A broad spectrum antibiotic of the aminoglycoside class, which inhibits growth of both gram-positive and gram-negative bacteria; sulfate salt is also used medicinally.

gentamicin

An aminoglycoside antibiotic used mainly for the treatment of serious GRAM NEGATIVE infections. Otherwise, gentamicin is used topically for external infections, such as those of the eye or ear. In large dosage it can cause TINNITUS, deafness and kidney damage. Recently, gentamycin has been shown to be capable of bypassing a STOP MUTATION and has been shown to be helpful in controlling CYSTIC FIBROSIS and other genetic disorders caused by stop mutations. The drug is on the WHO official list. Brand names are Cidomycin, Garamycin, Genticin and Minims gentamicin. See also PTC124.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

gen·ta·mi·cin

(jen'tă-mī'sin)
Broad spectrum aminoglycoside antibiotic that inhibits growth of both gram-positive and gram-negative bacteria.
References in periodicals archive ?
So we divided them into two equal groups- 16 patients were chosen for intratympanic gentamicin and the remaining 16 patients acted as control who were treated conservatively and not given intratympanic gentamicin, thus making it possible to compare the results between the two groups.
Asked whether he would recommend topical gentamicin on the basis of these findings, Mr.
Incubation of MDCK-C11 cells monolayers with 0.1 mM gentamicin sulfate determined a significant increase of [[[Ca.sup.2+]].sub.i] overtime as observed in the representative recording shown in Figure 1.
The results in Table I display a significant difference in mean serum creatinine level between the normal newborns group and the gentamicin treated group: the treated group had an increase in creatinine levels.
ant(2")-I gene was found in gentamicin resistant and gentamicin susceptible isolates at the rate of 34.77, and 22.35%, respectively.
AKI occurred despite the reduced gentamicin dose of 23 mg/kg ideal body weight (or adjusted body weight if obese).
fruit extract has proven equally effective against gentamicin induced nephrotoxicity.12
Intravesical gentamicin treatment of recurrent Escherichia coli urinary tract infections in a patient with multiple antibiotic allergies.
IT gentamicin application has been widely accepted in Meniere's disease because of the dominant vestibulotoxic effect of the agent [3, 4].
At 60 min, Gentamicin at 80 [micro]g/kg and 160 [micro]g/kg showed an increase in MRT by 92.30% and 136.29% when compared to control, whereas with aspirin, it increased by 124.27%.
[26] conducted a series of experiments to test the synergism effect of LFU and gentamicin on biofilm of P.