In recent years, reports on the occurrences of malignancies and other biological conditions in aquatic organisms following exposure to suspected genotoxins
Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin
Slot et al., "Bacterial genotoxin
triggers FEN1-dependent RhoA activation, cytoskeleton remodeling and cell survival," Journal of Cell Science, vol.
A biosensor for environmental genotoxin
screening based on an SOS lux assay in recombinant Escherichia co/icells.
A second OHSU project will study the effects of a potent genotoxin
present in the seed of the cycad, a tropical palm-like plant.
Neither of these solvents is considered a genotoxin
or a carcinogen; the weight of evidence from human in vivo studies suggests that exposure to toluene does not cause somatic cell genotoxic damage (7), although this view has been questioned by recent studies of rotogravure printers (8,9).
In addition to bacterial assays, MX is a direct-acting mutagen and genotoxin
in vivo (17-21) and in mammalian cells in vitro (21-27).
A final call in terms of in vivo genotoxicity was made for each substance listed in the EURL ECVAM and/or ECHA database, resulting in 10 substances identified as in vivo genotoxins
, while 4 others were considered non-genotoxic in vivo.
It is hypothesized that some intestinal bacteria potentiate intestinal carcinogenesis by producing genotoxins
, altering the immune response and intestinal microenvironment, and activating oncogenic signaling pathways .
Hofnung, "The SOS chromotest, a colorimetric bacterial assay for genotoxins
: procedures," Mutation Research/Environmental Mutagenesis and Related Subjects, vol.
The CBMN assay has in fact evolved into a "cytome" method for comprehensive measurement of chromosomal instability and altered cellular viability caused by genetic defects or exogenous genotoxins