This exceedingly low limit was reached by using established margin of exposure calculations for genotoxic carcinogens
, also known as DNA-reactive carcinogens, interact directly with DNA through the formation of covalent bonds, resulting in DNA-carcinogen complexes.
Published assessment of genotoxic carcinogens
, particularly dietary carcinogens, in mixtures is limited.
You see, genotoxic carcinogens
are capable of causing DNA damage and cancer, so it makes sense to me that breast cancer would logically ensue following exposure to mycotoxins.
The micronucleus test singles out genotoxic carcinogens
, or carcinogens that damage DNA.
Although the in vitro test battery demonstrates a high degree of sensitivity in detecting genotoxic carcinogens
, it is poor at correctly identifying noncarcinogens.
The experts also said fires at the works were also a source of genotoxic carcinogens
The ready quantifiable nature of sister chromatid exchanges with high sensitivity for revealing toxicant-DNA interaction and the demonstrated ability of genotoxic chemicals to induce significant increase in sister chromatid exchanges in cultured cells has resulted this endpoint being used as indicator of DNA damage in blood lymphocytes of individuals exposed to genotoxic carcinogens
Often being found in baked, fried or grilled foods, acrylamide is a suspected carcinogen and the UK Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment states that exposure to genotoxic carcinogens
should be as low as reasonably possible.
From there, specific types of dose--response relationship, such as the sometimes controversial hormesis mechanism and always controversial biological thresholds for genotoxic carcinogens
, are discussed, thereby supplementing the understanding of these latter critical concepts.
The associated genotoxic carcinogens
for several of these cancers, and also heart disease causation, are heterocyclic amines produced during the broiling and frying of creatinine containing foods such as meats.
However, in the present study, which was shorter term and used a lower dose, we found no change in oxidative DNA-damage-related gene expression, nor did we find a gene expression profile characteristic of a range of genotoxic carcinogens
, such as described by Ellinger-Ziegelbauer et al.