genotoxic


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Related to genotoxic: genotoxic carcinogen

genotoxic

 [je´no-tok″sik]
damaging to DNA; pertaining to agents (radiation or chemical substances) known to damage DNA, thereby causing mutations or cancer.

ge·no·tox·ic

(jē'nō-toks'ik),
Denoting a substance that by damaging DNA may cause mutation or cancer.
[gene + toxic]

genotoxic

adjective Referring to a factor or substance that causes chromosomal or DNA damage.

ge·no·tox·ic

(jē'nō-toks'ik)
Denoting a substance that by damaging DNA may cause mutation or cancer.
References in periodicals archive ?
It should be noted that the raining period may have influenced the results by diluting the samples, decreasing their genotoxic, mutagenic, and cytotoxic potential.
To date, there are no studies in the literature that evaluate the genotoxic potential of MMA simulating occupational exposure.
Some authors attribute the genotoxic effects mainly to resin acids (abietic and dehydroabietic acid; Fernandez et al., 2007) and sterols (Lehtinen et al., 1999) contained in the kraft mill effluents.
The genotoxic effects of thiocyclam was determined by comparing the number of aberrant cells in division stages for each dose of each pesticide with those of the concurrent negative control are presented in Tables 1, 2, and 3.
The study shows a distinct excess of cytogenetic damage in peripheral blood lymphocytes of policemen compared to indoor workers, highlighting the genotoxic consequences of the exposure to urban air pollutants.
The detection of genotoxic effects requires the use of concentration procedures or of highly sensitive detection systems that can be used for in situ monitoring.
The micronucleus test, is an in vivo and in vitro short-time screening test, developed by Schmid (1975) and Handle (1973) is widely used to detect genotoxic effects (He et.
If the calculated U value was less than the critical value from the table at the appropriate degrees of freedom (in our own case, [n.sub.1] = 4 and [n.sub.2] = 4) at the 0.05 probability then a statistically significant difference existed between the medians and the pesticide was adjudged to be genotoxic at the dose of the pesticide.
Together with structural and numerical chromosome aberrations, gene mutations are the key endpoints that need to be addressed when investigating the genotoxic potential of a compound.
These studies tested BT-11 under Good Laboratory Practice conditions in 90-day, repeat dose studies that evaluated general toxicity as well as toxicokinetic, metabolic, genotoxic, respiratory, cardiovascular, and central nervous system responses.