It should be noted that the raining period may have influenced the results by diluting the samples, decreasing their genotoxic
, mutagenic, and cytotoxic potential.
To date, there are no studies in the literature that evaluate the genotoxic
potential of MMA simulating occupational exposure.
Some authors attribute the genotoxic
effects mainly to resin acids (abietic and dehydroabietic acid; Fernandez et al., 2007) and sterols (Lehtinen et al., 1999) contained in the kraft mill effluents.
effects of thiocyclam was determined by comparing the number of aberrant cells in division stages for each dose of each pesticide with those of the concurrent negative control are presented in Tables 1, 2, and 3.
The study shows a distinct excess of cytogenetic damage in peripheral blood lymphocytes of policemen compared to indoor workers, highlighting the genotoxic
consequences of the exposure to urban air pollutants.
The detection of genotoxic
effects requires the use of concentration procedures or of highly sensitive detection systems that can be used for in situ monitoring.
The micronucleus test, is an in vivo and in vitro short-time screening test, developed by Schmid (1975) and Handle (1973) is widely used to detect genotoxic
effects (He et.
If the calculated U value was less than the critical value from the table at the appropriate degrees of freedom (in our own case, [n.sub.1] = 4 and [n.sub.2] = 4) at the 0.05 probability then a statistically significant difference existed between the medians and the pesticide was adjudged to be genotoxic
at the dose of the pesticide.
In recent years several studies have evaluated the impact of metals as genotoxic
Together with structural and numerical chromosome aberrations, gene mutations are the key endpoints that need to be addressed when investigating the genotoxic
potential of a compound.
These studies tested BT-11 under Good Laboratory Practice conditions in 90-day, repeat dose studies that evaluated general toxicity as well as toxicokinetic, metabolic, genotoxic
, respiratory, cardiovascular, and central nervous system responses.
Some anorectic drugs released for marketing do not have long-term use studies, especially in relation to their genotoxic