It should be noted that the raining period may have influenced the results by diluting the samples, decreasing their
genotoxic, mutagenic, and cytotoxic potential.
To date, there are no studies in the literature that evaluate the
genotoxic potential of MMA simulating occupational exposure.
Some authors attribute the
genotoxic effects mainly to resin acids (abietic and dehydroabietic acid; Fernandez et al., 2007) and sterols (Lehtinen et al., 1999) contained in the kraft mill effluents.
The
genotoxic effects of thiocyclam was determined by comparing the number of aberrant cells in division stages for each dose of each pesticide with those of the concurrent negative control are presented in Tables 1, 2, and 3.
The study shows a distinct excess of cytogenetic damage in peripheral blood lymphocytes of policemen compared to indoor workers, highlighting the
genotoxic consequences of the exposure to urban air pollutants.
The detection of
genotoxic effects requires the use of concentration procedures or of highly sensitive detection systems that can be used for in situ monitoring.
The micronucleus test, is an in vivo and in vitro short-time screening test, developed by Schmid (1975) and Handle (1973) is widely used to detect
genotoxic effects (He et.
If the calculated U value was less than the critical value from the table at the appropriate degrees of freedom (in our own case, [n.sub.1] = 4 and [n.sub.2] = 4) at the 0.05 probability then a statistically significant difference existed between the medians and the pesticide was adjudged to be
genotoxic at the dose of the pesticide.
In recent years several studies have evaluated the impact of metals as
genotoxic pollutants.
Together with structural and numerical chromosome aberrations, gene mutations are the key endpoints that need to be addressed when investigating the
genotoxic potential of a compound.
These studies tested BT-11 under Good Laboratory Practice conditions in 90-day, repeat dose studies that evaluated general toxicity as well as toxicokinetic, metabolic,
genotoxic, respiratory, cardiovascular, and central nervous system responses.
Some anorectic drugs released for marketing do not have long-term use studies, especially in relation to their
genotoxic effects.
