Some human diseases associated with genomic imprinting
That method sidestepped the problem of genomic imprinting
but presents ethical and practical hurdles if this technology were to ever be considered for humans.
Of particular interest in the DOHaD field is genomic imprinting
, an epigenetic phenomenon by which parent-of-origin-specific monoallelic gene expression is established during development (Bartolomei and Ferguson-Smith 2011; Das et al.
Daniela Di Tizio wrote the Status of Genomic Imprinting
of Human AFSCs and conceived the figures.
PAR supplementation gave promising results also in Prader-Willi syndrome (PWS), a genomic imprinting
disorder whose most important feature is severe obesity leading to atherosclerosis and type 2 diabetes mellitus, in which a close relationship with OS has been widely demonstrated .
Roles for genomic imprinting
and the zygotic genome in placental development.
: parental influence on the genome.
Assessments of DNA integrity, spindle configuration, aneuploidy and genomic imprinting
refers to differential expression of a locus between the maternally and paternally inherited alleles.
There is only limited evidence of genomic imprinting
in oviparous species, such as fish .
Family history has been observed in 10% of moyamoya patients (9) and familial moyamoya disease may be autosomal dominant with incomplete penetrance that depends on age and genomic imprinting
Two striking epigenetic phenomena in mammalians are X chromosome inactivation (XCI) and genomic imprinting
. XCI triggers the transcriptional silencing of most genes in all but one X chromosome in females (1), while genomic imprinting
is a process that leads to monoallelic gene expression based on parental origin (2).