The study -- the largest of its kind -- analysed survey responses and performed analyses known as genome-wide association studies
(GWAS) on data from more than 470,000 people who had given DNA samples and lifestyle information to the UK Biobank and to the U.S.
A preference for morning or evening is an example of such a trait, which the authors describe as a "chronotype." They note that a number of "large genome-wide association studies
" have generated robust genetic profiles for chronotype (i.e., morning or evening preference), sleep duration, and symptoms of insomnia.
Genome-wide association studies
(GWAS), using the chips, makes it possible to detect the genetic variants underlying the traits of interest.
Genetic data was used and a polygenic risk score was derived using data from MEGASTROKE, a large meta-analysis of genome-wide association studies
. Adherence to a healthy lifestyle was determined on the basis of four factors: non-smoker, healthy diet, body mass index (BMI) <30kg/[m.sup.2], and regular physical exercise.
To identify genetic variants that confer risk of both cardiovascular disease and Alzheimer's disease, the researchers used statistical techniques that allowed them to combine multiple large-scale genome-wide association studies
(GWAS) -- a type of genetic study that makes statistical links between various disease states and widely shared variations in the genetic code.
By far, most of the data in genome-wide association studies
, which have been critical in spotting genetic variants tied to common diseases, comes from people with European ancestry.
10, 2018 (HealthDay News) -- Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified, according to a meta-analysis of genome-wide association studies
(GWAS) published online Aug.
Identification of novel risk loci for restless legs syndrome in genome-wide association studies
in individuals of European ancestry: a meta-analysis, Lancet Neurology, October 10, 2017, DOI: 10.1016/S1474-4422(17)30327-7 http: //www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30327-7/fulltext
The recent genome-wide association studies
suggest that the "ABO" blood group antigen enhances the general body inflammatory state.
Rewritten, reorganized, and updated, this edition has 19 new plates and includes an overview of human evolution, aging, the CRISPR (Cluster Regularly Interspaced Short Palindromic Repeats)-Cas principle, genetic signaling pathways, genomic disorders and genome-wide association studies
, cancer genomes, laminopathies, chromatin disorders, cohesinopathies, and other emerging topics.
But, as genome-wide association studies
continue to reveal, most conditions are more complex, arising from dozens or hundreds of genetic mutations working together to cause disease.