genetic locus

ge·net·ic lo·cus

Each chromosome consists of a short arm and a long arm, which are joined at the centromere. The paired autosomes of the human genome are numbered in the order of decreasing length, 1 being the longest and 22 the shortest. Genes are arrayed in linear sequence along both arms of each chromosome. Differential staining permits their grouping in regions, bands, subbands, and sub-subbands. The standard designation of a gene locus consists of (1) chromosome number; (2) p for short arm, q for long arm; (3) region and band numbers, written together as a 2-digit numeral; (4) a period; (5) subband and sub-subband numbers, written together as a 2-digit numeral.
The set of homologous parts of a pair of chromosomes that may be occupied by allelic genes. The locus thus comprises a pair of locations (except in the X chromosome in males). The concept of a locus is somewhat idealized, not taking into account accidents that may occur in meiosis such as duplication of loci as a result of unequal crossing-over, translocations, and inversions.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
In bees whether an individual egg becomes a male or a female depends on a single genetic locus, known as the sex determination locus.
Performing genetic analysis of chinook salmon in Oregon's Rogue River, UC Davis scientists found a robust association between migration phenotype (spring run or fall run) and a single genetic locus. A dramatic change in allele frequency at this locus explained the rapid phenotypic shift that researchers observed after a recent dam construction.
The new study found that variations in a specific place in the genome - called a genetic locus - near the SIM1 gene are significantly associated with an increased risk of erectile dysfunction.
In this month's Primer, we're going to give an overview of a system, now a few years old and well developed, which allows for just this at-will selection of any unique genetic locus and its modification.
The genetic locus for X-linked Kallmann syndrome has been assigned to be X p 22.3, where the KAL-1 gene encodes Anosmin 1, which plays a role in normal migration of both GnRH secreting neurons and axons of olfactory neurons from the olfactory placode to the brain, thus linking anosmia with hypogonadotropism.
Gao et al .[sup][1] have already discovered that the genetic locus responsible for AI is located at chromosome 1p21.1-1q25.3 by genome-wide linkage scan, but could not identify any causal gene for the disease.
A report on genomewide linkage analysis of 24 Italian and 06 American families with IgAN identified a genetic locus, on chromosome 6q22 23 designated as IGAN1 (Gharavi, et al, 2000).
Geographic differences in genetic locus linkages for Borrelia burgdorferi.
FSP can also be classified according to the specific genetic locus (SPG) as SPG1" through SPG 48".
"These findings are truly exciting as possibly for the first time we have found a genetic locus for depression.
"This is truly exciting as we have found a genetic locus for the disease."
Many previous studies have identified a strong association between a genetic locus on 9p21 with cardiovascular disease outcomes, but the cause for this association was unknown.