genetic load


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Related to genetic load: balanced polymorphism

ge·net·ic load

the aggregate of more or less harmful genes that are carried, mostly hidden, in the genome that may be transmitted to descendants and cause morbidity and disease; in classic genetic dynamics, genetic load may be seen as undischarged genetic debts that result from previous mutations, each of which is supposed to exact an average number of lethal equivalents dependent only on the pattern of inheritance, regardless of how mild or severe the phenotype may be.

genetic load

n.
1. The relative difference between the theoretically most fit genotype within a population and the average genotype.
2. The aggregate of deleterious genes that are carried, mostly hidden, in the genomes of a population and may be transmitted to descendants.

ge·net·ic load

(jĕ-net'ik lōd)
The aggregate of more or less harmful genes that are carried, mostly hidden, in the genome and may be transmitted to descendants and cause disease.

genetic load

The totality of abnormalities caused in each generation by defective genetic material carried in the human gene pool.

genetic load

a measurement of the amount of deleterious genes in a population, calculated as the average number of lethal equivalents per individual.
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References in periodicals archive ?
Thus, although genetic counseling can potentially affect the genetic load of the offspring of patients by means of the mechanisms described above, it is less clear whether it can affect the genetic load of a population group, let alone how this can affect society.
genetic load is high in tetraploids where homozygous recessive genotypes
Children of group 2 and group 3 should be taken under medical supervision, as each subsequent child in a family with burdened history accumulates genetic load on this nosology by 6-8%.
Epistasis influences the rate at which the genetic load can be purged with inbreeding.
Evolution and low fertility in plants: pollen limitation, resource allocation, and genetic load. Trends Ecol.
This decline results from inbreeding depression, a symptom of genetic load (Busbice, 1968, 1996; Jones and Bingham, 1995; Kimbeng, 1996).
Furthermore, whereas long-domesticated species have had ample opportunity to purge deleterious alleles, large wild populations and semi-domesticated populations recently derived from them are much more likely to carry a high genetic load of deleterious alleles and thus suffer from inbreeding depression.
Most of the data on reduction of the genetic load are from studies of self-compatible plants.
High genetic load resolves two long-debated issues in bivalve genetics: (1) common distortions of Mendelian inheritance ratios in laboratory-reared progeny of wild parents (Wada 1975, Beaumont et al.
The mating system of a population will determine the levels of heterozygosity and hence the expression of the population's genetic load. If inbreeding depression is due to deleterious recessive or partially recessive alleles, expression of these alleles is enhanced by the increased homozygosity resulting from selfing.
Considerable genetic load may accumulate as selection against the self-progeny per se removes the opportunity to purge only the deleterious alleles (Uyenoyama et al.