genetic heterogeneity


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Related to genetic heterogeneity: Incomplete penetrance

ge·net·ic het·er·o·ge·ne·i·ty

the character of a phenotype produced by mutation at more than one gene or by more than one genetic mechanism. See: genocopy.

genetic

1. pertaining to reproduction or to birth or origin.
2. inherited.

genetic abnormality
inherited defect, which may or may not be congenital.
genetic analysis
analysis of breeding and pedigree records to establish degrees of relationship between single animals and groups of animals. Segregation analysis with full-sibling families is an obvious technique.
genetic code
the manner in which the arrangement of nucleotides in the polynucleotide chain of a chromosome governs the transmission of genetic information to proteins, i.e. determines the sequence of amino acids in the polypeptide chain making up each protein synthesized by the cell. Genetic information is coded in DNA by means of four bases (two purines: adenine and guanine; and two pyrimidines: thymine and cystosine). Each adjacent sequence of three bases (a codon) determines which of the 20 amino acids will be inserted into the nascent polypeptide.
genetic complementation
genetic control of inherited disease
consists of preventing carrier animals from contributing their genes to succeeding generations of the population of which they are members.
genetic correlation
a change in an unselected character resulting from selection of another character during a breeding program.
genetic defects
defects of function or structure passed on from parents to offspring. Inherited defects.
genetic determination
see broad-sense heritability.
genetic disease resistance
inherited resistance to diseases caused by non-hereditary risk factors.
genetic dominance
see dominance (2).
genetic drift
see antigenic drift.
genetic engineering
the manipulation of genes by recombinant DNA technologies to produce chromosomal combinations that are unlikely to occur by natural means, for example the introduction of genes for insulin into a yeast cell which then produces insulin which can be purified and used as a therapeutic substance. See also recombinant DNA technology.
genetic etiology
disease caused by inheritance of specific disease without the intervention of other risk factors; established by strongly positive relationship in terms of genes held in common between the affected patient and other affected individuals.
genetic evaluation
assessment, for predictive purposes, of productive improvement or conformational characteristics, of the gain to be derived by the use of the animal in question in a breeding program.
genetic expressivity
genetic heterogeneity
demonstrated by the way in which more than one disease with identical clinical signs can be inherited.
genetic immunization
use of a cloned genetically engineered gene with an encoded antigen to immunize the host against that antigen. See also DNA vaccine.
genetic map
the linear arrangement of genes along a chromosome. Called also linkage map.
genetic merit
inherited productivity or performance qualities.
mobile genetic elements
see transposable genetic elements (below).
genetic penetrance
genetic production potential
inherited productivity but still influenced by environmental risk factors.
genetic resistance
genetically determined resistance to specified infectious agents.
genetic selection
selection of animals as breeding stock on the basis of known inherited characteristics.
transposable genetic elements
pieces of DNA varying in length from a few hundred to tens of thousands of base pairs found in both prokaryotic and eukaryotic cells that move from place to place in the chromosomes of a single cell; some are viruses. Called also mobile genetic elements or transposons.
genetic variance
that portion of the phenotypic variance of a trait in a population which can be attributed to genetic difference amongst individuals.
References in periodicals archive ?
We agreed that HER2 genetic heterogeneity (GH) existed when between 5% and 50% of infiltrating tumor cells demonstrated gene amplification (a ratio of 2.
However, an unambiguous, clear definition of HER2 genetic heterogeneity is the first step toward the development of clinical studies to help answer the important question as to the clinical significance of this finding and the suitability of these patients for trastuzumab treatment.
The mutation detection rate of 85% of CF alleles with the analysis of only 13 CF mutations is surprising considering the genetic heterogeneity of the population of Southern Italy (5).
This result indicates that the nucleotide structures of the fiber gene and of E4 ORF 6/7 peptides might have contributed to the genetic heterogeneity during the Ad7 epidemics in Korea, whereas those of the hexon gene and E3 were highly conserved.
One example of genetic heterogeneity in one gene is described in a recent article by Nickerson et al.
In the 3 regions, the genetic heterogeneity observed between the sequences of the 11 AHFV isolates and KFDV strain was 7.
Because the expression of the disorders can be quite variable and CMT1A shows genetic heterogeneity, the DNA testing for these diseases establishes a secure diagnosis; it also permits genetic counseling and testing for high-risk family members.
Genetic heterogeneity of yellow fever virus strains from Africa and the Americas.
Genetic heterogeneity exists whereby different mutations may result in similar disease presentation.
Genetic heterogeneity in hereditary breast cancer: role of BRCA1 and BRCA2.
Genetic heterogeneity in Pneumocystis carinii: an introduction.