generalized vaccinia


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vaccinia

 [vak-sin´e-ah]
the cutaneous and sometimes systemic reactions associated with vaccination with smallpox vaccine. See also cowpox and paravaccinia.
vaccinia gangreno´sa generalized vaccinia with failure to develop antibodies against the virus (due to agammaglobulinemia), with spreading necrosis at the site and metastasis of lesions throughout the body.
generalized vaccinia a condition of widespread vaccinial lesions resulting from sensitivity response to smallpox vaccination and delayed production of neutralizing antibodies.
progressive vaccinia vaccinia gangrenosa.

gen·er·al·ized vac·cin·i·a

secondary lesions of the skin following vaccination that may occur in subjects with previously healthy skin but are more common in the case of traumatized skin, especially in the case of eczema (eczema vaccinatum). In the latter instance, generalized vaccinia may result from mere contact with a vaccinated person. Secondary vaccinial lesions may also occur following transfer of virus from the vaccination to another site by means of the fingers.
References in periodicals archive ?
new cases (May 10-June 20) Adverse events Suspected + Probable (ss) Eczema vaccinatum -- ** -- Fetal vaccinia -- -- Generalized vaccinia 1 -- Inadvertent inoculation, nonocular 1 -- Ocular vaccinia -- -- Progressive vaccinia -- -- Erythema multiforme major -- -- (Stevens-Johnson syndrome) Myo/pericarditis 2 2 Post vaccinial encephalitis or -- -- encephalomyelitis Pyogenic infection of vaccination site -- -- No.
new cases (April 14-18) Adverse events Suspended + Probable (ss) Eczema vaccinatum - ** - Erytherma multiforme major - - (Stevens-Johnson syndrome Fetal vaccinia - - Generalized vaccinia 1 - Inadvertent inoculation (nonocular) 2 - Myocarditis/Pericarditis 1 - Ocular vaccinia - - Postvaccinial encephalitis or - - encephalomyelitis Progressive vaccinia - - Pyogenic infection of vaccination - - site No.
new cases (April 5-13) Adverse events Suspected + Probable (ss) Eczema vaccinatum -- ** -- Erythema multiforme major (Stevens- -- -- Johnson syndrome) Fetal vaccinia -- -- Generalized vaccinia 1 -- Inadvertent inoculation (nonocular) 7 -- Myocarditis/Pericarditis 3 -- Ocular vaccinia -- -- Postvaccinial encephalitis or -- -- encephalomyelitis Progressive vaccinia -- -- Pyogenic infection of vaccination -- -- site No.
new cases (March 31-April 4) Adverse events Suspected + Probable (ss) Confirmed (n) Eczema vaccinatum -- ** -- -- Erythema multiforme major -- -- NA ++ (stevens-Johnson syndrome) Fetal vaccinia -- -- -- Generalized vaccinia -- -- -- Inadvertent inoculation, 5 -- -- nonocular Myocarditis/pericarditis 2 1 -- Ocular vaccinia -- -- -- Postvaccinial encephalitis or -- -- NA encephalomyelitis Progressive vaccinia -- -- -- Pyogenic infection of -- -- -- vaccination site Total no.
new cases (March 11-30) Adverse events Suspected + Probable (ss) Eczema vaccinatum -- ** -- Erythema multiforme major (Stevens- -- -- Johnson syndrome) Fetal vaccinia -- -- Generalized vaccinia 5 -- Inadvertent inoculation, nonocular 14 -- Myocarditis/Pericarditis 1 3 Ocular vaccinia -- -- Postvaccinial encephalitis or -- -- encephalomyelitis Progressive vaccinia -- -- Pyogenic infection of vaccination -- -- site No.
One moderate-to-severe adverse event was reported, a suspected case of generalized vaccinia in a woman aged 39 years.
cases Adverse events Suspected Probable Potentially life-threatening events Eczema vaccinatum -- + -- Erythema multiforme major -- -- (Stevens-Johnson syndrome) Fetal vaccinia -- -- Post-vaccinial encephalitis or -- -- encephalomyelities Progressive vaccinia -- -- Moderate-to-severe events Generalized vaccinia -- -- Inadvertent inoculation, non- -- -- ocular Ocular vaccinia -- -- Pyogenic infection of vaccination -- -- site No.

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