The term "generalized lentiginosis" is often reserved for such patients who have widespread lentigines without systemic abnormalities.
Generalized Lentiginosis is a condition in which numerous lentigines, in no characteristic distribution, are widespread over the body; however, it should be noted that the term "generalized lentiginosis" is usually applied in the literature to cases in whom visible cutaneous signs are neither accompanied by mucosal involvement nor by systemic developmental anomalies of the central nervous system, the endocrine system, the mental development, or the bowels.
The absence of systemic abnormalities and the abrupt onset pattern differentiate eruptive Lentiginosis are seen in LEOPARD syndrome, Carney complex, and generalized Lentiginosis. (30) Familial Lentiginosis syndromes are associated with an increased incidence of neural, endocrine, and mesenchymal tumors.
(17, 18) In this case other than congenital generalized lentiginosis, Deaf-mutism, esophagitis and melena no other specific clinical findings suggestive of lentiginosis syndromes available in the literature.
Generalized Lentiginosis in two children lacking systemic associations: case report and review of the literature.
Generalized lentiginosis. J Am Acad Dermatol 1988; 18: 444-7.
Generalized lentiginosis manifesting through three generations.