general paralysis of the insane

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general paralysis of the insane (GPI)

A now rare form of dementia from SYPHILIS of the nervous system. GPI was a feature of the third (tertiary) stage of untreated syphilis and occurred 10–20 years after infection in a small proportion of cases. The condition is characterized by delusions of grandeur, mania and sometimes delusions of persecution.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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