gene suppression


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gene suppression

The situation in which a normal PHENOTYPE develops in an individual or cell with a mutant gene due to a second mutation either in the same gene or in a different gene.
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There is an introduction to technologies for gene suppression as well as molecular diagnostics to detect and monitor gene expression.
A battery of different tests conducted on rat livers found that sunflower oil induced fibrosis, gene suppression and high levels of oxidation.
Short hairpin RNA (shRNA) has become a staple of the research community for silencing genes, but identifying the most effective shRNA sequence to provide the greatest level of gene suppression often presents a problem.
Many reports have demonstrated that introduction of siRNAs into mammalian cells may lead to unintended gene suppression via RNAi-independent and/or RNAi-mediated mechanisms.
Cilation: "Increase developmental plasticity of human keratinocytes with gene suppression;" Shengwen Calvin Li, et al.; Proceedings of the National Academy of Sciences, 18 July 2011, DOI: 10.1073/pnas.1100509108
The hypothesis was that the gene suppression would act like a clogged pipe, creating an abundance of compounds that would have later become phenylalanine in a normal plant.