Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing
In his new role, Jorgen will be able to critically contribute to the manufacturing efforts to progress Silence's three significant sets of assets in gene silencing
siRNA: SLN124, for the treatment of iron overload disorders, SL360, for the treatment of cardiovascular disease, and SL500 with partner Mallinckrodt Pharmaceuticals, for the treatment of complement-mediated disorders.'
Earlier this month Silence agreed a partnership with Mallinckrodt to develop and commercialise gene silencing
treatments for serious diseases worth an upfront US$20mln.
treatment A "life-changing" asthma jab and a novel "gene silencing
" treatment for people with a rare hereditary disease have been approved for use in Scotland.
RNAi (RNA interference) is reportedly a natural cellular process of gene silencing
that represents one of the most promising and rapidly advancing frontiers in biology and drug development today.
Instead, what was covalently linked to the platform was the multiple gene silencing
and cell-targeting site, which consisted of two linear small hairpin RNA transcription templates for RNAi and gene therapy, a cell-specific unit for specific recognition and insertion by the tumor cell, and a disulfide linkage to be cleaved by cellular glutathione.
Among their topics are high-throughput screenings: new breeze in anti-Trypanosoma cruzi drug discovery, protein glycosylation in Trypanosoma cruzi and strategies based on mass spectrometry for characterizing glycans and glycoproteins, omics approaches for understanding gene expression in Leishmania: clues for tackling Leishmaniasis, Entamoeba histolytica: from high-throughput technology to new drugs, and gene silencing
and therapeutic targets against Acanthamoeba infections.
Different geminiviral proteins from different viruses may act as suppressors of gene silencing
; their strength and mode of action may also differ like TrAP, C4, and V2 (Vanitharani et al., 2004; Amin et al., 2011).
This is mediated by small RNA comprised of 21-23 nucleotides length termed siRNA, specifically directing cleavage of complementary mRNA targets in a procedure that is commonly considered to be an antiviral cellular defense mechanism.16,17 RNAi is a widespread silencing mechanism that acts at the transcriptional levels by a RNAi effector complex called RNA-induced initiation of transcriptional gene silencing
.18 RNAi gene silencing
at the posttranscriptional and transcriptional levels can be applied to gene therapy.
IL-17 Expression and Th17 Cell Differentiation under MBD2 Gene Silencing
We are exploring creative approaches to develop the next generation of innovative genomics tools in the area of gene silencing
and manipulation for biomedical research and therapeutic applications.