gene silencing


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gene silencing

The inhibition of transcription of a gene. DNA METHYLATION is an important cause of gene silencing and when this affects tumour-suppressor genes may be a cause of cancer.

gene silencing

A therapeutic technique to prevent the expression of genes that are acting harmfully. Double-stranded RNA molecules introduced into cells with viral vectors are processed by an enzyme known as dicer. This frees short interfering RNA segments (siRNAs) which are then unzipped into two RNA strands. These then produce a complex which binds to the complementary RNA coding for a protein thus preventing the synthesis of the protein. The potential for gene silencing seems considerable and may have a role in the management of cancer by blocking angiogenesis and of wet age-related macular degeneration and diabetic retinopathy.
References in periodicals archive ?
Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
In his new role, Jorgen will be able to critically contribute to the manufacturing efforts to progress Silence's three significant sets of assets in gene silencing siRNA: SLN124, for the treatment of iron overload disorders, SL360, for the treatment of cardiovascular disease, and SL500 with partner Mallinckrodt Pharmaceuticals, for the treatment of complement-mediated disorders.'
Earlier this month Silence agreed a partnership with Mallinckrodt to develop and commercialise gene silencing treatments for serious diseases worth an upfront US$20mln.
treatment A "life-changing" asthma jab and a novel "gene silencing" treatment for people with a rare hereditary disease have been approved for use in Scotland.
RNAi (RNA interference) is reportedly a natural cellular process of gene silencing that represents one of the most promising and rapidly advancing frontiers in biology and drug development today.
Instead, what was covalently linked to the platform was the multiple gene silencing and cell-targeting site, which consisted of two linear small hairpin RNA transcription templates for RNAi and gene therapy, a cell-specific unit for specific recognition and insertion by the tumor cell, and a disulfide linkage to be cleaved by cellular glutathione.
Among their topics are high-throughput screenings: new breeze in anti-Trypanosoma cruzi drug discovery, protein glycosylation in Trypanosoma cruzi and strategies based on mass spectrometry for characterizing glycans and glycoproteins, omics approaches for understanding gene expression in Leishmania: clues for tackling Leishmaniasis, Entamoeba histolytica: from high-throughput technology to new drugs, and gene silencing and therapeutic targets against Acanthamoeba infections.
The aim of this proposal is to explain a recently discovered interplay between mrna methylation, Gene silencing and gene expression in plants.
Different geminiviral proteins from different viruses may act as suppressors of gene silencing; their strength and mode of action may also differ like TrAP, C4, and V2 (Vanitharani et al., 2004; Amin et al., 2011).
This is mediated by small RNA comprised of 21-23 nucleotides length termed siRNA, specifically directing cleavage of complementary mRNA targets in a procedure that is commonly considered to be an antiviral cellular defense mechanism.16,17 RNAi is a widespread silencing mechanism that acts at the transcriptional levels by a RNAi effector complex called RNA-induced initiation of transcriptional gene silencing.18 RNAi gene silencing at the posttranscriptional and transcriptional levels can be applied to gene therapy.
IL-17 Expression and Th17 Cell Differentiation under MBD2 Gene Silencing or Overexpression.
We are exploring creative approaches to develop the next generation of innovative genomics tools in the area of gene silencing and manipulation for biomedical research and therapeutic applications.