Families of thalassemia patients also show very high gene frequency
. Studies show that in Pakistan carrier rate in these families vary between 31 - 68% in comparison to 5% in general population.
When gene frequency
for the first allele at each locus is low in the initial population, the response to selection for yield is greater in the first five to six cycles, after which the response slows down (Fig.
(3) The very rare allele 4 (gene frequency
< 0.01) uniquely expresses 2531T, which defines the [Sit.sup.a] alloantigen.
For a given gene frequency
, the degree of the downward bias is partly dependent on the sampling of different subdivisions and individuals within subdivisions For balanced data from r random mating populations of size n (i.e., one-level hierarchy), the expected bias of estimated intraclass correlation [Mathematical Expression Omitted] is approximated by (cf.
The syndrome is due to an autosomal recessive gene with a gene frequency
of 15 per 1000 population.
Mutation (G) gene frequency
is 50% and the wild gene (A) frequency is 50%.
Statistical analysis: Pearson chi-square ([chi square]) test was performed to find the statistical significance between the genotypes, and the gene frequency
was calculated by allele counting.
Estimating the prevalence of pyruvate kinase deficiency from the gene frequency
in the general white population.
Each germplasm population, in the B[C.sub.2][F.sub.3] generation, is expected to have a resistant gene frequency
of approximately 50%.
The gene frequency
for the A allele was 27.1%, which is similar to that described by other studies (2).
Quantification of the amount of temporal gene frequency
shifts over extended periods of time is of interest for understanding the dynamics of genetic change in natural populations and because it also provides a means for estimation of the genetically effective population size, [N.sub.e].
If trapping bias exists, empirical estimates of gene frequency
could be seriously affected.