gene dose

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gene dose

Genetics The number of copies of a particular gene present in a genome. See Gene, Genome.

References in periodicals archive ?

Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers.

Morphine/codeine ratio, a key in investigating a case of doping

This paper reports the characterization of a group of patients with primary lung cancer regarding the gene dose at loci corresponding to EGFR, PIK3CA and C-myc genes in tumor cells, compared with those found in adjacent lung tissue with normal phenotype from the same patients.

Specificity and sensitivity of a gene dose increase as neoplastic marker can be expressed as the fraction of pathologically determined tumor tissues of the group where measured gene dose exceeds a given threshold.

Oncogene amplification as tumor marker in a group of Colombian lung cancer patients/Amplificacion oncogenica como marcador tumoral en un grupo de pacientes con cancer pulmonary

Gene dose of apoliprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

An overview of the environmental genome project

This was accomplished by expressing the CYP2D6 genotype in terms of semi-quantitative CYP2D6 gene dose. These investigators applied a process they termed "allele-specific change of concentration on identical background" (ASCOC).

Functional gene dosages were calculated, based on measured ASCOC values for individual alleles, by defining the reference gene dose as having a value of 2 (Table 1).

Fine-tuning pharmacogenetics: paradigm for linking laboratory results to clinical action

From the results reported above, it is possible to calculate a quantitative "functional gene dose" (FGD).

To allow comparison with published data, we assigned a semiquantitative gene dose (SGD) of 1 for functional alleles, 0 for completely dysfunctional null alleles (e.g., *4), and 0.5 for the *41 and *10 alleles.

Peak areas can also be used to quantify gene dose (24, 25).

The HER2/neu copies for each tumor and cell line were compared with HER2/neu copies of the MRC cell line (single-copy control) to obtain the degree of amplification or gene dose. The gene dose was then compared with reported values for the cell lines (12, 28, 29).

Quantification of HER2/neu gene amplification by competitive PCR using fluorescent melting curve analysis

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

Improved method for genotyping apolipoprotein E polymorphisms by a PCR-based assay simultaneously utilizing two distinct restriction enzymes

Identifying associations in regions like this where X-chromosomal gene doses are not balanced between men and women can be particularly valuable in helping us to understand why some characteristics differ between sexes, he continues.