(9) suggested that the over expression of genes located on the X chromosome may have a gene dosage effect
and may cause the developmental anomalies in the genitourinary system of triple X patients.
We have analyzed the expression of 5 Hsa21 miRNAs in trisomic fetal hearts at 18-22 gestational weeks to investigate whether they are affected by the gene dosage effect
observed for most of the Hsa21 genes.
"We found a gene dosage effect
, the more unfavourable variations a woman has, the greater her ovarian cancer risk and the shorter her survival time," said senior author Xifeng Wu, M.D., Ph.D., professor in M.
Proteolipid protein gene dosage effect
in Pelizaeus-Merzbacher disease.
Although mutations within the PMP22 gene have been identified in some cases of CMT1A and HNPP, a gene dosage effect
has been proposed as the principal underlying pathomechanism for development of CMT1A and HNPP (9-11).
Conducted in compliance with The Code of Practice for Care and Use of Animals for Experimental Purposes, the study directed to assess the gene dosage effects
of Gabrb2 in (HT) (KO) mice genotypes -- displayed deficiency of prepulse inhibition (PPI) to a significantly lesser extent in both the mice.
It appears, however, that the comprehensive DS phenotype cannot be accounted for on the basis of gene dosage effects
Transcript level alterations reflect gene dosage effects
across multiple tissues in a mouse model of Down syndrome.
The phenotypic expression of a chromosomal interchange can vary dramatically, from partial sterility (Hanson,1952) and skewed ratios due to differential gamete transmission of Dp-Df gametes (Phillips et al.,1971; McKenzie et al.,1970), to subtle or no change due to genetic buffering and gene dosage effects
. Selfing [F.sub.1] plants heterozygous for a single interchange results in varying dosage combinations of the genes located on segments involved in the interchange.