gene dosage compensation

gene dos·age com·pen·sa·tion

the putative mechanism that adjusts the X-linked phenotypes of males and females to compensate for the haploid state in males and the diploid state in females. It is now largely ascribed to lyonization which compensates the mean of the dose but not its variance, which is greater in females.
See also: lyonization.

gene dos·age com·pen·sa·tion

(jēn dō'săj kom'pĕn-sā'shŭn)

The putative mechanism that adjusts the X-linked phenotypes of males and females to compensate for the haploid state in males and the diploid state in females. It is now largely ascribed to lyonization, which compensates the mean of the dose but not its variance, which is greater in females.

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References in periodicals archive ?

The genetic sources of variation can be associated with the presence of the extra maternal set of chromosomes and can involve simple gene dosage (additivity) between chromosome sets or positive or negative dosage compensation effects (heterosis), epigenetic mechanisms, and transcriptional co-suppression (negative gene dosage compensation) [19].

Studies on gene dosage compensation in the allotriploid endemic Iberian minnow showed that the allelic expression patterns differ between genes and between different tissues [20].