gene disruption

gene disruption

or

gene knock-out

disruption of a target gene by the directed insertion of DNA into it using the process of RECOMBINATION. In this way the gene is inactivated. Used to investigate gene function.
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In data to be presented at ASH, we will demonstrate high levels of gene disruption of adult human hematopoietic stem cells with CRISPR/Cpf1 and efficient targeted integration at the beta-hemoglobin locus with CRISPR/Cas9.
Further characterization by virulence studies on isolates with this stx2c subunit A gene disruption might provide further insights into the mild illness caused by this strain.
Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.
Our results support the notion that CRISPR/Cas9 system is a swift, robust and useful tool for targeted gene disruption, deletion and editing.
Targeted gene disruption of HSP70-2 results failledmeosis, germ cell apoptosis and male infertility.
Thus, the abnormal phenotypes are the consequences of the gene disruption, position effect or deletion at one of the break points resulting in haploinsufficiency of critical X linked genes.
US-based Transposagen Biopharmaceuticals has received two patents, the first named 'Nucleic Acids Encoding Hyperactive PiggyBac Transposases' on 19 March 2013, and the second entitled, 'A Genetically Modified Rat Comprising a Cytokine Gene Disruption and Exhibiting a Greater Susceptibility to a Cytokine-Mediated Autoimmune and/or Inflammatory Disease', on October 15, 2013, it was reported yesterday.
ISLAMABAD -- Researchers at Virginia Tech have successfully used a gene disruption technique to change the eye colour of a mosquito - a critical step toward new genetic strategies aimed at disrupting the transmission of diseases such as dengue fever.
Washington, Mar 22 ( ANI ): Researchers at Virginia Tech have successfully used a gene disruption technique to change the eye color of a mosquito - a critical step toward new genetic strategies aimed at disrupting the transmission of diseases such as dengue fever.
This concept has been used in designing the ura-blaster gene constructs as a tool in multiple gene disruption experiments in S.
Vasanthakrishna Mundodi, Ashwini S Kucknoor and Lashitew Gedamu: Role of Leishmania chagasi amastigotecysteine protease in intracellular parasite survival: Studies by gene disruption and antisense mRNA inhibition.