gene disruption

gene disruption

or

gene knock-out

disruption of a target gene by the directed insertion of DNA into it using the process of RECOMBINATION. In this way the gene is inactivated. Used to investigate gene function.
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The p53 finding "doesn't mean CRISPR is toast," according to the report, which said CRISPR Therapeutics' sickle-cell and thalassemia programs as well as Editas Medicine's lead product, targeting a form of blindness, and others in its pipeline, all use NHEJ gene disruption, which is one of two paths for CRISPR to edit genomes.
Further characterization by virulence studies on isolates with this stx2c subunit A gene disruption might provide further insights into the mild illness caused by this strain.
Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.
High-throughput PCR tailing for gene disruption has been developed in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius [1].
Our results support the notion that CRISPR/Cas9 system is a swift, robust and useful tool for targeted gene disruption, deletion and editing.
Targeted gene disruption of HSP70-2 results failledmeosis, germ cell apoptosis and male infertility.
Thus, the abnormal phenotypes are the consequences of the gene disruption, position effect or deletion at one of the break points resulting in haploinsufficiency of critical X linked genes.
In a cohort of 171 PCC tumors from The Cancer Genome Atlas (TCGA), the frequency of gene disruption for three of these complex components was remarkably high (RBX1, 30.4%; VHL, 26.9%; CUL5, 21.6%), while two remaining complex components exhibited the modest disruption frequencies in PCC tumors: TCEB1 (6.4%) and TCEB2 (2.9%).
US-based Transposagen Biopharmaceuticals has received two patents, the first named 'Nucleic Acids Encoding Hyperactive PiggyBac Transposases' on 19 March 2013, and the second entitled, 'A Genetically Modified Rat Comprising a Cytokine Gene Disruption and Exhibiting a Greater Susceptibility to a Cytokine-Mediated Autoimmune and/or Inflammatory Disease', on October 15, 2013, it was reported yesterday.
ISLAMABAD -- Researchers at Virginia Tech have successfully used a gene disruption technique to change the eye colour of a mosquito - a critical step toward new genetic strategies aimed at disrupting the transmission of diseases such as dengue fever.