Some foci had gemistocyte aggregation and a few ganglion cells that were accompanied by mild infiltration of chronic inflammatory cells throughout (figure 2, B).
3) The tumor we describe belongs in this category, although our case is unique in view of our distinguishing findings of the absence of fibrosis and neuronal tissue and the presence of abundant gemistocytes, mild vascular proliferation, perivascular cuffing, mild cellular anaplasia, and mitoses.
These authors explain T1 hyperintensity from the protein hydration layer inside the cytoplasm of swollen gemistocytes appearing after an acute cerebral injury.
Other authors suggest that high T1 signal could be related to manganese accumulation on gemistocytes [9].
At the end of all this process, astrocytes are stimulated and observation of
gemistocytes which are swelled reactive astrocytes and neuronal loss and gliosis in the striatal region in acute and chornic injuries in autopsy studies is explained in this way (9,11).
Changes were characterized by white matter spongiosis with numerous digestion chambers containing phagocytosing myelinophages and scattered interstitial
gemistocytes.
Histologically, they consist of bland spindle-shaped and polygonal fibrous astrocytes, or large cells with glassy, eosinophilic cytoplasm, similar to
gemistocytes of subependymal giant cell astrocytoma.
Gemistocytes were first described by Franz Nissl as glia (gemaestete glia) with voluminous cytoplasm.
Although gemistocytes may be found in all grades of astrocytoma (II, III, and IV), gemistocytic astrocytoma is currently recognized as a distinct variant only of diffuse astrocytoma (WHO grade II).
Additional features, if present (1) Hemosiderin deposition (2) Calcification (3) Microcyst formation (4) Mitotic activity (5) Pleomorphism (6) Presence of gemistocytes (7) Vascular proliferation (8) Necrosis d.
The presence of gemistocytes, vascular proliferation, and necrosis represent negative prognostic indicators, and the latter 2 histologic changes are diagnostic of high-grade astrocytomas.
