gemeprost

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gemeprost

Obstetrics A PG analogue administered vaginally, used with mifepristone–RU 486 as an abortifacient; it is safe but expensive, and requires specific conditions for storage and transportation. See Abortion, Misoprostol, Prostaglandin, RU 486, Sulprostone.

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Misoprostol (alone) in second trimester terminations of pregnancy: as effective as Gemeprost? J Obstet Gynaecol 2006; 6: 9-546.

A COMPARISON OF COMPLICATIONS IN PREVIOUS CAESAREAN WITH NON CAESAREAN CASES UNDERGOING MISOPROSTOL INDUCED MID TRIMESTER ABORTIONS

A randomised controlled trial comparing two intravaginal misoprostol regimens and gemeprost for mid-trimester termination of pregnancy.

EFFECT OF LOWERING THE DOSE OF MISOPROSTOL FOR SECOND TRIMESTER TERMINATION OF PREGNANCY ALONG WITH MIFEPRISTONE

A 43-year-old primigravida underwent pregnancy termination with gemeprost at the 13th gestational week.

A Potentially Useful Addition to Predict Spontaneous Resolution of Uterine Artery Pseudoaneurysm: Absence of Diastolic Flow

The review included studies of regimens using mifepristone with gemeprost, mifepristone with oral misoprostol, mifepristone with vaginal misoprostol, methotrexate with vaginal misoprostol, and vaginal misoprostol only.

Infection rate after medical abortion is very low

The approved regimens in Great Britain and Sweden provide that the prostaglandin gemeprost be administered vaginally.

Mifepristone for early medical abortion: experiences in France, Great Britain and Sweden. (Special Report)

Two prostaglandins used early on in conjunction with RU486 in France, gemeprost and sulprostone, were largely abandoned after one of the four women suffering heart attacks died in 1992.

Jettisoned Ultrasound and Training Requirements May Have Prevented Tragedies Deaths, Ruptured Tubes, Heart Attacks Among RU486 Users, Distributor Reports

Benedetti and others suggested that there are safer alternatives to misoprostol for cervical ripening and/or labor induction, including dinoprostone, gemeprost, and oxytocin, although some of these agents cost $90 per dose.

Hospitals Restrict Misoprostol Use

The results of the French study, which analyzed the effectiveness of RU 486/oral misoprostol in 488 women (study 1), confirmed that the ongoing pregnancy rate with 400 ug oral misoprostol is four times higher (four women, 0.8%) than that found in Britain using gemeprost (1 woman, 0.2%).

Citizen Petition to the Food and Drug Administration

She returns to the clinic 48 hours later and is given a second drug, a prostaglandin (in France, an oral version called misopristol is used; in Great Britain and Sweden, a vaginal suppository called gemeprost is used).

Birth-control business

Parity is a major determinant of success rate in medical abortion: a retrospective analysis of 3161 consecutive cases of early medical abortion treated with reduced doses of mifepristone and vaginal gemeprost. Contraception 2000;62(6):297-303.

Comparative study of the efficacy of mifepristone with vaginal misoprostol and vaginal misoprostol alone for first trimester abortion

The frequency of infection was highest among those who received mifepristone followed by gemeprost (1.6%) but much lower amongst those treated with mifepristone and oral misoprostol (0.2%).