In comparison, Figure 2 shows that treatment of PANC-1 cells with gemcitabine
increased the percentage of cells in S phase to 60.1 [+ or -] 6.0% and reduced the percentage in the G0/G1 phase to 28.7 [+ or -] 4.2%.
"The low doses of the extract greatly boosted the effectiveness of gemcitabine
. We also found that lower doses of the conventional drug were needed.
Key Words: Gemcitabine
; bladder, carcinoma, bacillus calmette-guerin BCG) failure.
Light yellow powders of platycodin D were used as testmaterial, and white crystalline powders of gemcitabine
Rogel Cancer Center laboratory researchers, led by Meredith Morgan, PhD, found that AZD1775 prevented pancreatic cancer from protecting itself against the effects of radiation and gemcitabine
, while leaving normal cells relatively unaffected.
In the human study, IVC was administered during radiation therapy while participants received ongoing treatment with gemcitabine
. Fifteen subjects were enrolled in the experimental group, and 19 subjects were selected from the records of the hospital to be used as historical comparators.
Currently, CAN04 is combined with cisplatin and gemcitabine
in a clinical phase IIa study in non-small cell lung cancer (NSCLC).
FA and gemcitabine
were purchased from Sigma-Aldrich Chemical Company (USA).
TUESDAY, May 8, 2018 (HealthDay News) -- Immediate post-resection intravesical installation of gemcitabine
is associated with reduced recurrence over four years for patients with suspected low-grade non-muscle-invasive urothelial cancer, according to a study published in the May 8 issue of the Journal of the American Medical Association.
An alternative to temozolomide is gemcitabine
, which is still under evaluation for use as a potential radiosensitizer.
Although cytotoxic chemotherapies such as doxorubicin [2-4], gemcitabine
[5-7], and docetaxel [5, 8] can provide temporary benefit in some patients with metastatic leiomyosarcoma, these agents have modest clinical effectiveness [9,10].