gelsolin


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Related to gelsolin: Profilin

gel·so·lin

(jel-sol'in), [MIM*137350]
An actin-binding protein; a Ca2+-triggered actin-filament-severing protein; hence, it has roles in locomotion, secretion, and endocytosis.

gelsolin

(jĕl′sŏl′ĭn)
n.
A calcium-regulated actin-binding protein that breaks cytoskeletal actin filaments into smaller pieces, thus transforming the actin network (or gel) into a colloidal solution and influencing cell morphology, motility, and apoptosis.
References in periodicals archive ?
Benefits Can Be Explained by Plasma Gelsolin Enhancing the Host Inflammatory Response to Infection
Witke, "Gelsolin and diseases," Subcellular Biochemistry, vol.
Bulle Oliveira, "Corneal lattice dystrophy type II-familial amyloid neuropathy type IV (gelsolin amyloidosis)," Einstein, vol.
Among insoluble lens proteins, vimentin, gelsolin, gamma enolase like protein, filensin like protein and ATP synthase subunit B were found from lenses of Uromastyx hardwickii.
There were no differences in mean CSF gelsolin level between 0 and 24 hours in all groups.
Kelly, "Heparin accelerates gelsolin amyloidogenesis," Biochemistry, vol.
Garland et al., "Duplicated gelsolin family genes in zebrafish: a novel scinderin-like gene (scinla) encodes the major corneal crystallin," FASEB Journal, vol.
Gelsolin down-regulates lipopolysaccharide-inducedintraamniotic tumor necrosis factor-a production in the midtrimester of pregnancy.
Loss of overall cell shape is probably due to the cleavage of cytoskeletal proteins such as fodrin and gelsolin (Kothakota, 1997) and finally the plasma membrane blebbing seems to be caused by the cleavage of PAK2, a member of the p21-activated kinases family (Rudel and Bokoch, 1997).
We have identified [beta]-actin, tropomyosin, gelsolin and myosin (non-muscle) as the binding partners of MT-3.
Caspase-3 action occurs downstream in the apoptotic pathway and involves in cleaving important substrates such as gelsolin, fodrin, actin, and poly ADP-ribose (Todor et al., 2002).
Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines.