gelatinase


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gel·a·tin·ase

(jĕ-lat'i-nās),
Pepsin B; a metalloproteinase that hydrolyzes gelatin and a number of types of collagen. See: pepsin.

gelatinase

(jĕl′ă-tĭn-ās),

MMP-2; MMP-9

Metalloproteinases that cleave gelatin, or nondenatured collagen. Two forms of gelatinase, A and B, have been identified. Gelatinase A (MMP-2) has a molecular weight of about 72,000, and gelatinase B (MMP-9) has a molecular weight of about 92,000. Both are involved in cancer angiogenesis and metastasis and are blocked by a variety of naturally occurring and synthetic inhibitors.
References in periodicals archive ?
When analyzing the localization in a three-layer Percoll gradient, which can separate not only the main organelles, azurophil granules, and specific granules, from the light membrane fraction, but also the gelatinase granules from the somewhat denser specific granules (Figure 1 upper panel), it is clear that the PAFR cannot be found in the granules (Figure 1 lower panel).
Human dentin contains collagenase (MMP-8), gelatinases MMP-2 and -9, and others.
For combustion emissions exposures (e.g., filtered air vs SDCCA) and SOA exposures, a Student t-test was used to compare PCR, LPO, and gelatinase activity data.
Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis.
This antibiotic has in vitro activity against collagenase and gelatinase, and in animal studies it reduced the severity of OA.
9:10 "Inhibition of scleral gelatinase A activity by captopril." Francine Johnson *, Virginia R.
Jourquin et al., "Gelatinase B and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia," European Journal of Neuroscience, vol.
Several new markers have become topics of research, with studies mainly focused on CysC (Cystatin c), KIM-1 (kidney injury molecule 1), and NGAL (neutrophil gelatinase associated lipocalin).