pylori infection, gastrotoxic medication) should be questioned in patients with gastric resection to identify predisposing factors that can be different from those in the normal stomach .
pylori infection, biliary reflux, histologic features of the gastric mucosa, gastrotoxic treatment (nonsteroidal anti-inflammatory drugs (NSAIDs), antiplatelet therapy), comorbidities, and social habits for gastric stump ulcer occurrence.
Surprisingly, none of the known major risk factors for gastric ulcer (gastrotoxic drugs, H.
It is believed that among patients with gastric resections, the use of the gastrotoxic medication has a similar effect.
Biliary reflux and alcohol consumption, but not Helicobacter pylori infection or gastrotoxic drug consumption, are the most important predictors for ulcer recurrence in patients with gastric surgery for peptic ulcer disease after more than 15 years.
We considered gastrotoxic drug exposure the nonsteroidal anti-inflammatory drugs (NSAIDs) consumption as regular daily doses in patients with arthritis or other inflammatory disorders who needed chronic therapy (more than six months).
The GSTT1 null genotype was associated with an increased risk, without statistical significance (OR = 1.82, 95% CI: 0.72, 4.74) in patients without drug intake, while GSTT1 null genotype was associated with a decreased risk with no statistical significance (OR = 0.47, 95% CI: 0.21, 1.07) in patients with gastrotoxic treatments.
We questioned also the interplay between GST gene polymorphisms and the rest of environmental risk factors known to increase the susceptibility for endoscopic/histologic gastric lesions (gastrotoxic medication, smoking, and alcohol consumption).
Hence, in the presence of gastrotoxic drug consumption (NSAIDs and/or antiplatelet drugs) the presence of GSTT1 null genotype decreased the risk for gastric atrophy/intestinal metaplasia.
The GST polymorphisms seem to play a role in gastric cancer disease in our population, modulated by exposure to various exogenous factors (smoking, alcohol, gastrotoxic drugs, and H.
Tutin, a toxic compound of sesquiterpene extracted from Coriaria sinica Maxim (Coriariaceae: Coriaria), has neurotoxic, gastrotoxic
, and antifeedant effects in many insects, and inhibits pathogenic microorganisms, such as Botryosphaeria berengeriana Notaris.
(3) The preferential inhibition of COX 1 by traditional NSAIDs is thought to be responsible for their gastrotoxic
effects by affecting the regulation of homeostatic functions in the gastric mucosa.