gastroparesis


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Related to gastroparesis: gastroenteritis, vagus nerve

gastroparesis

 [gas″tro-pah-re´sis]
paralysis of the stomach; called also gastroparalysis and gastroplegia.

gas·tro·pa·re·sis

(gas'trō-pă-rē'sis, -par'ĕ-sis),
Weakness of gastric peristalsis, which results in delayed emptying of the bowels.
[gastro- + G. paresis, a letting go, paralysis]

gastroparesis

(găs′trō-pə-rē′sĭs, -păr′ĭ-sĭs)
n. pl. gastropare·ses (-sēz′)
A disorder characterized by delayed movement of food from the stomach into the small intestine because of impaired stomach motility, resulting in nausea, vomiting, and a feeling of fullness.

gastroparesis

Partial paralysis of gastric smooth muscle, resulting in retention of food.

Aetiology
Autonomic neuropathy due to diabetes, gastric surgery, vagal nerve damage, viral infections, medications (e.g., anticholinergics and narcotics), gastro-oesophageal reflux disease (GERD/GORD), smooth muscle disease (amyloidosis, scleroderma), metabolic disease (e.g. hypothyroidism).

Clinical findings
Abdominal pain, nausea, vomiting, bloating, loss of appetite, gastric muscle spasms, variable glucose levels.

Diagnosis
Upper GI endoscopy, ultrasonography, radio contrast studies, gastric emptying scintigraphy, breath test, Smart Pill.

gas·tro·pa·re·sis

(gas'trō-păr-ē'sis)
A slight degree of gastroparalysis.
[gastro- + G. paresis, a letting go, paralysis]

Gastroparesis

Nerve damage of the stomach that delays or stops stomach emptying, resulting in nausea, vomiting, bloating, discomfort, and weight loss.
Mentioned in: Sildenafil Citrate

gas·tro·pa·re·sis

(gas'trō-păr-ē'sis)
Weakness of gastric peristalsis, resulting in delayed emptying of the bowels.
[gastro- + G. paresis, a letting go, paralysis]

Patient discussion about gastroparesis

Q. is anyone following a diet for gastroparesis? i developed a bezoar in the stomach, as a result of gastroparesis and it caused internal bleeding, was wondering of anyone else has or knows someone who has had a similar experience

A. brandon

well i had vegus nerve severed also many years ago (forty or so) never gave me trble till recently everything seems ok rite now, but i think it may br an ongoing thing

thanks

Q. I have just been diagnosed with gastroparesis. I'am looking for more info on treatment and experiences...

A. In most cases, treatment does not cure gastroparesis—it is usually a chronic condition. Treatment helps you manage the condition so you can be as healthy and comfortable as possible..there are medications that helps like Metoclopramide (Reglan) that stimulates stomach muscle contractions to help emptying. and dietary changes (having 6 small meals instead of big three..) and there even clinical trials with Botulinum Toxin that might be helpful, but still in research.

More discussions about gastroparesis
References in periodicals archive ?
Parkman, "Effect of dietary fat and food consistency on gastroparesis symptoms in patients with gastroparesis," Neurogastroenterology and Motility, vol.
The subjects were divided into four groups: (1) DGP group: 71 patients with T2DM who met the diagnostic criteria for gastroparesis, their fasting plasma glucose 7.8-14.6 mmol/L, average fasting plasma glucose 11.2 [+ or -] 3.2 mmol/L; (2) simple diabetes group: 92 patients with T2DM who did not meet the diagnostic criteria for gastroparesis, their fasting plasma glucose 7.5-14.4 mmol/L, average fasting plasma glucose 10.1 [+ or -] 2.9 mmol/L; (3) non-DGP (NDG) group: 52 nondiabetic patients who met the diagnostic criteria for gastroparesis; and (4) normal group: 123 nondiabetic patients who did not meet the diagnostic criteria for gastroparesis.
Gastric cancer, reflux, gastritis, indigestion, stomach ulcers, epigastria burning , unexplained vomiting, gastroparesis (delayed gastric emptying) and stomach irritability are common in gastric diseases [6].
The high blood glucose in our patient possibly can be explained by volume depletion and secondary renal failure, thus impeding further glucose excretion, and the presence of diabetic gastroparesis. Gastric emptying is unpredictable and it makes blood glucose difficult to control.
Then, we passed by 68 papers through screening the title and the abstract due to the non-RCT but case reports, clinical observations, animal experimental studies, mechanism research studies, repetition papers, diabetic gastroparesis, and literature reviews.
Gastroparesis stays silent as long as the patient is in a fasting state and triggered by ingestion of food or liquids5.
Gastric neuromodulation with Enterra system for nausea and vomiting in patients with gastroparesis. Neuromodulation: Technology at the Neural Interface 2012; 15(3):224-231.
Amie and her mum started researching her symptoms and finally learned about Gastroparesis, and it was this which was eventually diagnosed.
This report provides comprehensive information on the therapeutic development for Diabetic Gastroparesis, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
The patient's other medical problems include diabetes mellitus type 2, cerebrovascular accident, depression, hypertension, hyperlipidemia, atherosclerotic cardiovascular disease, colostomy secondary to diverticulitis, gastroparesis, esophageal dysmotility, vitamin B12 deficiency and Addison's disease.
Relamorelin has already completed Phase 2 trials for the treatment of diabetic gastroparesis and chronic constipation.
Diabetic gastroparesis (prevalence: 30-40% of DM patients) is a condition characterized by delayed gastric emptying in the absence of mechanical obstruction of the stomach owing to autonomic neuropathy (2).