ganglioside


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Related to ganglioside: cerebroside

ganglioside

 [gang´gle-o-sīd]
a class of galactose-containing cerebrosides found in central nervous system tissues; they are glycolipids of the basic composition ceramide-glucose-galactose-N-acetyl neuraminic acid. The form GM1 accumulates in tissues in generalized gangliosidosis, the form GM2 in Tay-Sachs disease.

gan·gli·o·side

(gang'glē-ō-sīd),
A glycosphingolipid chemically similar to cerebrosides but containing one or more sialic (N-acetylneuraminic or N-glycolylneuraminic) acid residues; found principally in nerve tissue, spleen, and thymus; ganglioside GM1 accumulates in generalized gangliosidosis; GM2 accumulates in Tay-Sachs disease.

ganglioside

/gan·glio·side/ (gang´gle-o-sīd) any of a group of glycosphingolipids found in the central nervous system tissues and having the basic composition ceramide-glucose-galactose-N -acetylneuraminic acid. The form GM1 accumulates in tissues in GM1 gangliosidoses and the form GM2 in GM2 gangliosidoses.

ganglioside

(găng′glē-ə-sīd′)
n.
Any of a group of galactose-containing cerebrosides found in the surface membranes of nerve cells.

ganglioside

[gang′glē·əsīd′]
a glycosphingolipid found in the brain and other nervous system tissues. Gangliosides are members of a group of galactose-containing cerebrosides with a basic composition of ceramide-glucose-galactose-N-acetyl neuraminic acid. Accumulation of gangliosides caused by an inborn error of metabolism results in gangliosidosis or Tay-Sachs disease.

gan·gli·o·side

(gang'glē-ō-sīd)
Glycosphingolipid chemically similar to cerebrosides but containing one or more sialic acid residues; found principally in nerve tissue, spleen, and thymus; GM1 accumulates in generalized gangliosidosis; GM2 accumulates in Tay-Sachs disease.

ganglioside

A compound of fat and carbohydrate (glycolipid) that is an important component in cell membranes.

Ganglioside

A fatty (lipid) substance found within the brain and nerve cells.
Mentioned in: Tay-Sachs Disease

ganglioside

a class of galactose-containing cerebrosides found in central nervous system tissues; they are glycolipids of the basic composition ceramide-glucose-galactose-N-acetyl neuraminic acid. The form GM1 accumulates in tissues in generalized gangliosidosis as observed in Friesian cattle, dogs and cats. The form GM2 accumulates in a similar disease of Yorkshire pigs, dogs and cats.
References in periodicals archive ?
1995) Ewes' milk: changes in the contents of gangliosides and sialic acid during lactation.
Ganglioside preparations first came to market in Italy in the 1980s and were marketed into China by TRB Pharma S.
Mice missing ganglioside GD3 on the membranes of neural stem cells had much smaller supplies of the cells in these key areas throughout life and expressed signs of lost hope with behaviors such as not actively seeking dry land when placed in water, Yu said.
GM1 ganglioside is based on a natural brain chemical that plays an important role in the development, survival, and activities of neurons.
Its drug discovery projects include two ongoing lead optimisation programmes, inhibition of heparan sulfate synthesis for MPS III and other MPS disorders and inhibition of ganglioside synthesis for Tay Sachs and Sandhoff diseases.
Washington, December 1 ( ANI ): Parkinson's patients treated with the experimental drug GM1 ganglioside showed improved symptoms during a two and a half-year trial, according to Thomas Jefferson University researchers.
Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside.
7% of the GBS patients, probably because of late reporting to the hospitals and though high intensity of anti gangliosides antibodies were present in the different subgroups of GBS patients, the NC patients also had adequate anti ganglioside antibodies compared to the NNC patients in whom the specific antibodies were nearly absent.
While there is no consistent proof for pathogens as inducers of ADs, except in acute rheumatic fever where Streptococcus pyogenes share a structural similarity to N-acetyl-b-D-glucosamine, and in Guillain-Barre syndrome where Camphylobacter jejuni shares a structural homology with the peripheral nerve GM1 ganglioside, there are many theories (Christen 2010).
Similarly, at ASCO 2008, investigators in the phase III EORTC (European Organisation for Research and Treatment of Cancer) 18961 trial reported that an adjuvant vaccine that was targeted against a ganglioside that was overexpressed on most melanoma cells did not improve distant metastasis-free survival, and that an early interim analysis suggested a detriment to overall survival.
Simultaneously, the cell membrane receptor for CT was identified to be a specific ganglioside, GM1, which was arguably the first ever chemically fully defined biologic receptor (4,5).