ganciclovir implant

ganciclovir implant

AIDS An ocular implant that delivers ganciclovir directly into the vitreous cavity in CMV retinitis. See Cytomegalovirus retinitis.
References in periodicals archive ?
Robinson, "Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant," The New England Journal of Medicine, vol.
Genotypic analysis of cytomegalovirus retinitis poorly responsive to intravenous ganciclovir but responsive to the ganciclovir implant. Am J Ophthalmol 2003; 135: 20-25.
[5] Certain HIV specialists recommend the use of oral valganciclovir with intraocular ganciclovir implant for initial therapy (especially for patients with immediate site-threatening retinitis), but some experts recommend the use of oral valganciclovir alone for initial therapy mainly because of its ease of administration and lack of requirement for ophthalmologic surgery or placement of an indwelling catheter.
Fourteen patients were excluded from the final analysis for the following reasons: absence of photographic confirmation of CMV retinitis at study entry (5); noncompliance with study therapy (4); absence of efficacy data reported after randomization (3); presence of a ganciclovir implant in one eye (1); and no receipt of any doses of study drug (1).
CMV has been called the 'neglected disease of the AIDS pandemic', in part because of limited access to treatment, especially in the developing world, where localised intra-ocular ganciclovir implants and systemic oral valganciclovir are unavailable or too costly.