gammopathy


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Related to gammopathy: polyclonal gammopathy

gammopathy

 [gam-mop´ah-the]
abnormal proliferation of the lymphoid cells producing immunoglobulins; the gammopathies include multiple myeloma, macroglobulinemia, and Hodgkin's disease. Called also gammaglobulinopathy.
monoclonal g's plasma cell dyscrasias.

gam·mop·a·thy

(gă-mop'ă-thē),
A primary disturbance in immunoglobulin synthesis.

gammopathy

An abnormal ↑ in immunoglobulin production; monoclonal gammopathies–MGs are usually malignant Examples Myeloma, Waldenström's disease, CLL, heavy-chain disease, but may also be benign, appearing in amyloidosis and MG of undetermined significance; polyclonal gammopathies are usually benign and appear in inflammatory conditions–eg, angioimmunoblastic lymphadenopathy, cirrhosis, leishmaniasis, rheumatoid arthritis, SLE, TB. Note: Polyclonal gammopathies may occur as epiphenomena in lymphomas, Hodgkin's disease, metastatic adenoCA. See Biclonal gammopathy, Monoclonal gammopathy of undetermined significance.

gam·mop·a·thy

(gă-mop'ă-thē)
A primary disturbance in immunoglobulin synthesis.

gammopathy

Any abnormality, in quality or quantity, of the IMMUNOGLOBULINS present in the blood. Benign monoclonal gammopathy is an abnormal production of a single clone of an immunoglobulin. Gammopathies are associated with MYELOMATOSIS.
References in periodicals archive ?
In April 2017, the International Kidney and Monoclonal Gammopathy Research Group (IKMG) redefined MGRS as a clonal proliferative disorder that produces a nephrotoxic monoclonal immunoglobulin and does not meet previously defined hematological criteria for treatment of a specific malignancy (12).
The physiopathological significance of benign monoclonal gammopathy: A study of 64 cases.
In conclusion, we present the case of a patient with scleromyxedema without concomitant monoclonal gammopathy and draw attention to hydroxychloroquine treatment.
A majority of participant laboratories (66.6%; 499 of 749) kept a file on all known monoclonal gammopathy patients to assist in review (Table 6, question L).
Keywords: Monoclonal gammopathy of undetermined significance, Prevalence, Serum Protein Electrophoresis, Age increment, Erythrocyte sedimentation rate, Anemia.
Taken together with the patient's lack of symptoms, the low (<1.0 g/dL) concentration of the monoclonal protein and a normal ratio of free [kappa] to free [lambda] light chains, the IgG [kappa] finding suggested a diagnosis of monoclonal gammopathy of undetermined significance.
Koshino et al., "A Case of Diffuse Panbronchiolitis(DPB) with Benign Monoclonal IgA Gammopathy and IgA Nephropathy with Monoclonal IgA Deposition," Japanese Journal of Medicine, vol.
Benveniste, "Sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance," Current Opinion in Neurology, vol.
The electrophoresis and immunofixation revealed an IgM kappa monoclonal gammopathy. The rest of the blood work was negative.
While the combination of polycythemia and PCM is rare, there are rare syndromes that are characterized by both polycythemia and a monoclonal gammopathy, and these syndromes should always be in the differential in patients with both a monoclonal plasma cell process and polycythemia.
Other conditions associated with pediatric PG include leukemia, IgA monoclonal gammopathy, Crohn's disease, rheumatoid arthritis, Takayasu disease and various immunodeficiency states including HIV, chronic granulomatous disease, and hyper IgE syndrome.
We should suspect this entity in adult patients, usually older than 40, with a chronic urticarial rash associated with any of the following signs or symptoms: fever, fatigue, general malaise, arthralgia, enlarged liver, or spleen, enlarged lymph nodes, leukocytosis and/or increased markers of inflammation, monoclonal gammopathy and a neutrophilic infiltrate on skin biopsy (2).