IL2RG

(redirected from gammaC)

IL2RG

A gene on chromosome Xq13.1 that encodes the gamma subunit of interleukin-2 (IL-2) receptor, which forms a heterotrimer with alpha and gamma subunits resulting in a high-affinity IL-2 receptor. The gamma chain is an important signalling component of many IL receptors, including those of IL-2, IL-4, IL-7 and IL-21, and is thus referred to as the common gamma chain.

Molecular pathology
Defects in IL2RG cause X-linked severe combined immunodeficiency (XSCID), as well as the less severe X-linked combined immunodeficiency (XCID).
References in periodicals archive ?
Grealy et al., "Post-operative infection and sepsis in humans is associated with deficient gene expression of gammac cytokines and their apoptosis mediators," Critical Care, vol.
Using an increase in outdoor unit power draw of 1.8% per GAMMAC rise in outdoor temperatures (Stephens et al., 2011) and an outdoor temperature of 105 GAMMAF (41GAMMAC) during the peak hour, the average peak power draw across all individual units is likely 4.2 kW (std.
Severe cutaneous papiliomavirus disease after haemopoietic stem-cell transplantation in patients with severe combined immune deficiency caused by common gammac cytokine receptor subunit or JAK-3 deficiency.