cys·ta·thi·o·nine γ-ly·ase

(sis'tă-thī'ō-nēn lī'ās),
A liver enzyme, requiring pyridoxal phosphate as coenzyme, which catalyzes the hydrolysis of l-cystathionine to l-cysteine and 2-ketobutyrate, releasing NH3; also catalyzes formation of 2-ketobutyrate from l-homoserine, of pyruvate (and NH3 and H2S) from l-cysteine, and of thiocysteine, pyruvate, and NH3 from cystine. A deficiency of this enzyme results in cystathioninuria. It catalyzes a step in methionine catabolism and in cysteine biosynthesis.
See also: cystathionine β-lyase.


/γ-cys·ta·thi·o·nase/ (sis″tah-thi´o-nās) a pyridoxal phosphate–containing enzyme that catalyzes the hydrolysis of cystathionine to cysteine, ammonia, and α-ketoglutarate; deficiency results in cystathioninuria.
Full browser ?