gamma-butyrolactone


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γ-butyrolactone

Industrial solvent and purported health additive. Precursor in the synthesis of γ-hydroxybutyric acid.

gamma-butyrolactone

(găm′ə-byo͞o′tə-rə-lăk′tōn′)
n. Abbr. GBL
A chemical that has many industrial uses, especially as a solvent. It is a chemical precursor to gamma-hydroxybutyrate and is ingested illegally for its euphoriant and sedative effects.

gam·ma-bu·ty·ro·lac·tone

(GBL) (gam'ă-byū'tir-ō-lak'tōn)
An industrial and household solvent that is readily metabolized after oral ingestion to gamma-hydroxybutyrate (GHB). Like GHB, it is marketed illicitly as a euphoriant, appetite suppressant, antidepressant, and sleep aid. It is more potent than GHB and has both a more rapid onset and a longer duration of action, but its pharmacologic and toxic properties are essentially the same: nausea, bradycardia, and central nervous system depression ranging from drowsiness and confusion to seizures, coma, and death. Dependency and severe withdrawal symptoms have been reported.
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References in periodicals archive ?
Optimum High Performance Liquid Chromatography Parameters for the Quantitation of Gamma-hydroxybutyrate and Gamma-butyrolactone.
Gamma-butyrolactone (GBL) withdrawal presenting as acute psychosis, Journal of Toxicology Clinical Toxicology (1999) 37:651.
Adverse events reported with the use of gamma-butyrolactone products marketed as dietary supplements, Journal of Toxicology Clinical Toxicology (1999) 37:649.
Improved pharmacological activity via pro-drug modification: Comparative pharmacokinetics of sodium gamma-hydroxybutyrate and gamma-butyrolactone, Research Communications in Chemical Patholology and Pharmacology (1978) 22:107-118.

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