Assuming the presence of compounds with a similar activity as galanthamine
, they should contain about 1% of an active compound, or if present at lower levels, even compounds more active than galanthamine
Drug application: Substances used in this experiment included TDE (dissolved in ethanol), atropine, ACh and galanthamine
(dissolved in dd[H.
Bulbs grown at 1,400ft in the Black Mountains produce twice as much galanthamine
as those planted in Pembrokeshire at sea level.
Two small earlier studies have suggested that galanthamine
, a reversible acetylcholinesterase inhibitor, might be useful for alcohol dependence.
In the United States, clinical trials of the new galanthamine
derivatives may begin within a year, Kosley says.
There are many drugs which are reported potent inhibitors of the enzyme, like physiostigmine, neostigmine, tacrine, and galanthamine
etc  However, galanthamine
(an alkaloid) is highly selective for AChE and it has achieved considerable superiority to physiostigmine and tacrine for the treatment of AD.
In addition, the compounds showed greater inhibitory activity on AChE than galanthamine
, a well known acetylcholinesterase inhibitor (47).
As reported in the previous Legal and Regulatory Update, (7) Eisai with the support of Shire Pharmaceuticals has been seeking to challenge guidance issued by the UK National Institute of Health and Clinical Excellence (NICE) in January 2001 that restricts the availability of certain Alzheimer's drugs belonging to the class of acetylcholinesterase inhibitors, namely donepezil, rivastigmine and galanthamine
, to certain categories of patient only.
By-products from daffodils, such as galanthamine
- to treat memory loss - could create lucrative markets.
And the common daffodil contains galanthamine
, used in the treatment of Alzheimer's disease.
Angustidine (2), nauclefine (3), angustine (4), angustoline (6) and harmane (7) showed higher BChE inhibiting potency compared to galanthamine
Dr Ainsworth is also a director of Powys-based company Alzeim, which is producing the registered drug Galanthamine
from daffodils which slows the progression of the condition Alzheimer's.