galactose-alpha-1,3-galactose

A carbohydrate found in many nonhuman mammalian tissues. It can stimulate delayed immune responses, esp. food allergies, in sensitized people who eat meat.

Synonym: alpha-gal

References in periodicals archive ?

The presence of the epitope galactose-alpha-1,3-galactose ([alpha]Gal) synthesized by alpha-1,3-galactosyltransferase ([alpha]GT) on the surface of porcine cells induces HAR [4,5].

Alpha-1, 3-galactosyltransferase-deficient miniature pigs produced by serial cloning using neonatal skin fibroblasts with loss of heterozygosity

The findings were published by the scientific journal Nature Biotechnology as a correspondence entitled Chinese Hamster Ovary Cells Can Produce Galactose-alpha-1,3-Galactose Antigens on Proteins.

Momenta finds CHO cells can produce antigens on proteins

The unique part on this monoclonal antibody drug responsible for these cross-reactions was determined to be the carbohydrate structure galactose-alpha-1,3-galactose; found on both the monoclonal antibody protein and beef proteins.