Prospective cohort study of nephrogenic systemic fibrosis in patients with stage 3-5 chronic kidney disease undergoing MRI with injected gadobenate dimeglumine or gadoteridol
Kumar, "Biodistribution of radiolabeled, formulated gadopentetate, gadoteridol
, gadoterate, and gadodiamide in mice and rats," Investigative Radiology, vol.
Closely related diagnostic agents are gadobenate dimeglumine (MultiHance), gadodiamide (Omniscan), gadofosveset (Ablavar), gadopentetate dimeglumine (Magnevist), gadoteridol
(Prohance), and gadoversetamide (OptiMARK).
2 1) Gadoteridol
2) Gadobenate dimeglumine 3) Iomeprol 400 mg / ml 4) Iomeprol 350mg/ml Package No.
Various MR contrast agents are available on the market--gadodiamide (Omniscan), gadopentetate (Magnascan), gadoteridol
There are five gadolinium-based contrast agents approved for use in the United States: gadodiarnide, gadoversetamide (OptiMARK), gadopentetate dimeglumine (Magnevist), gadoteridol
(ProHance), and gadobenate dimeglumine (Multihance).
These agents are gadodimide (Omniscan[R]), gadoversetamide (OptiMARK[R]), gadopentetate dimeglumine (Magnevist[R]), gadoteridol
(ProHance[R]), and gadobenate dimeglumine (MultiHance[R]).
Currently, there are four gadolinium-based contrast agents available commercially in the U5: gadodiamide (Omniscan; Amersham Health), gadopentetate dimeglumine (Magnevist; Schering), gadoversetamide (OptiMARK; Mallinckrodt Medical), and gadoteridol (Prohance; Bracco).
The stability constant of gadoteridol, which is another chelate that does not affect the OCP method, is 25.
Also, Group II gadolinium-based agents, such as gadoteridol
and gadobenate dimeglumine, should be used rather than Group I agents like gadodiamide and gadopentatate dimeglumine, which are associated with the greatest number of NSF cases.
13) A mild case of NSF has been documented following multiple exposures to gadoteridol
(ProHance, Bracco Diagnostics, Inc.
Wayne, NJ) Gadobenate dimeglumine (Gd-BOPTA) (MultiHance, Bracco Diagnostics, Princeton, NJ) Nonionic and linear Gadodiamide (Gd-DTPA-BMA) (Omniscan, GE Healthcare, Princeton, NJ) Ionic and cyclic Gadoterate meglumine (Gd-DOTA) (Dotarem/Artirem, Guerbet SA, Roissy, France) Nonionic and cyclic Gadoteridol
(Gd-HP-DO3A) (ProHance, Bracco Diagnostics) Gadobutrol (Gd-DO3A-butriol) (Gadovist, Berlex Laboratories) Table 2.