G-glutamylcysteine synthetase | definition of g-glutamylcysteine synthetase by Medical dictionary
gamma-glutamylcysteine synthetase (redirected from g-glutamylcysteine synthetase)
an enzyme that catalyzes the first step in glutathione biosynthesis, reacting l-glutamate, l-cysteine, and ATP to form γ-glutamylcysteine, ADP, and orthophosphate; inhibited by thiols such as glutathione and cysteamine.
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References in periodicals archive
subtilis B10 treatment induced high gene expression levels of glutathione S-transferases (GST) and g-glutamylcysteine synthetase (g-GCS) in RAW 264.7 cells.
While, g-glutamylcysteine synthetase (g-GCS) is a rate-limiting enzyme in de novo synthesis of GSH and it plays a pivotal role in GSH homeostasis (Hibi et al., 2004).
Two enzymes are used in the synthesis of glutathione: g-glutamylcysteine synthetase
(g-Glu-CysSyn), and glutathione synthetase (GS).