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A necessary precursor in the biosynthesis of glutathione; contains an isopeptide rather than a eupeptide bond.
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The goal of this study was to examine the influence of exercise training and type I diabetes on the activity of aconitase and superoxide dismutase (SOD), on levels of reduced glutathione (GSH), on the expression of genes responsible for glutathione synthesis (Gclc, g-glutamylcysteine synthase; Gss, glutathione synthetase), and on the expression of genes responsible for the formation of two potassium channels (Kcnd2, [I.
2003), and its levels reflect the degree of oxidative challenge placed upon the tissue, g-glutamylcysteine synthase is responsible for catalyzing the synthesis of g-glutamylcysteine from glutamic acid and cysteine, and glutathione synthetase then catalyzes the synthesis of GSH from g-glutamylcysteine and glycine; the second reaction is ATP-dependent (Huang et al.