fusion inhibitors

fusion inhibitors

A new class of antiviral drugs that function by preventing the fusion of the virus with the cell membrane of the host cell. These drugs can reduce plasma levels of HIV in patients in whom standard combinations of antiretroviral drugs are no longer effective. See ENFUVIRTIDE.
References in periodicals archive ?
On The Basis Of Type: , Reverse Transcriptase Inhibitors, Protease Inhibitors, Fusion Inhibitors & Immune System Modulators
Enanta believes EDP-938 is differentiated from fusion inhibitors currently in development by others for RSV because this N-protein inhibitor targets the virus' replication machinery and has demonstrated high barriers to resistance against the virus in vitro.
The HIV can still replicate but the resulting virions are immature and cannot infect new cells (Figure 2); (iv) fusion inhibitors act by blocking the fusion of HIV envelope with the host CD4 cell membrane, thus preventing the entry of HIV into the CD4 cells; (v) chemokine receptor antagonists (CCR5 Antagonists) act by blocking the CCR5 coreceptor and prevent HIV from entering the cell; (vi) integrase inhibitors work by stopping the virus from integrating with DNA of human cells.
Drugs such as fusion inhibitors (FIs), reverse transcriptase inhibitors (RTIs), and protease inhibitors (PIs) have been developed and applied in the various optimal control problems.
In the group of patients benefitting from ALK fusion inhibitors (n = 18), all were nCounter positive while 3 were negative or not evaluable by FISH.
Peptide and non-peptide HIV fusion inhibitors. Curr Pharm Des 2002;8(8):563-580.
Anti-HIV-1 agents known as fusion inhibitors target the N-HR or C-HR and disrupt their association, which prevents the virus from entering into the host cell.
Thus, it is particularly sad that Roche, who sponsored the research into fusion inhibitors and developed the first PIs has just announced its withdrawal from research in the HIV field.
Antiretroviral drugs for the treatment of HIV are classified into 4 categories: nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs) and fusion inhibitors (FIs).
(9) ARV drugs that do not appear to affect liver enzymes and are therefore not expected to change levels of contraceptive hormones include nucleoside reverse transcriptase inhibitors (NsRTIs), such as zidovudine, stavudine, and lamivudine; nucleotide reverse transcriptase inhibitors (NtRTIs), such as tenofovir; and fusion inhibitors, such as enfurvitide.
There are currently four Food and Drug Administration (FDA)-approved classes of antiretroviral drugs in general use: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), and fusion inhibitors.