Dong quai, which is often taken for menstrual cramps, contains natural coumadin and furocoumarin
For each extract the furocoumarin
imperatorin was quantitatively characterized by FIPLC-DAD (Fig.
1 A), a dietary furocoumarin
, was wide spread and found not only in the medicinal plant such as Cnidium monnieri (L) cusson and Angelica dahurica (Fisch.
A clinical trial by Partonen (1998) demonstrated that administration of furocoumarin
psoralen inhibited hepatic melatonin metabolism to treat seasonal affective disorders in humans in Finland.
Phytophotodermatitis from furocoumarin
exposure (limes or celery) presents with irregular, linear erythema and blisters.
Fukuda K, Ohta T, Oshima Y, Ohashi N, Yoshikawa M, Yamazoe Y:Specific CYP 3 A4 inhibitors in grapefruit juice: furocoumarin
dimmers as components of drug interaction.
Molecular and genetic basis of furocoumarin
In the case of berloque dermatitis, the phototoxic reaction is induced by the effect of long-wave ultraviolet (UVA) radiation on bergapten, or 5- methoxypsoralens, a furocoumarin
now known to be the only photoactive component of bergamot oil.
aurantium also contains a furocoumarin
(bergapten) that inhibits CYP3A4.
Beer, beef and mushrooms contain carcinogens such as hydrazine, furocoumarin
and ethyl carbamate.
The concentration of furocoumarin
is variable between species and between different parts of the same plant.
Limes, as well as celery and parsley, contain furocoumarin
, an agent that makes skin more sensitive to the sun.