Here, we aim to define our experience with intravenous (i.v.) recombinant (G-CSF) administrations for 5 days followed by a single-dose of 20 mg of IA endotoxin to induce IA inflammation, necrotizing funisitis
, and fetal brain/lung injury in the preterm goat model.
Placentitis refers to inflammation of the chorioallantois, often caused or complicated by infective agents and frequently extending to the amnion (amnionitis) and the umbilical cord (funisitis
They include morphologic anomalies of the umbilical cord (both in length and in thickness), true knots, cord prolapse, traction or torsion, velamentous insertion of the cord, vessel wall abnormalities, umbilical cord cysts, abdominal trauma in pregnancy, postterm pregnancy, infections (chorioamnionitis and funisitis
), deficiency of Wharton's jelly, congenital defects, and many more remain unexplained .
There was no evidence of funisitis
or umbilical cord vasculitis to support a diagnosis of chorioamnionitis nor were any pathogens observed.
and our group have demonstrated that the presence of intra-amniotic infection (with reported incidences of 13.6% for preterm labor and 38% for preterm premature rupture of membranes) [5, 6], funisitis
, and fetal inflammatory response syndrome (FIRS, defined as an elevated fetal plasma interleukin-6 level (>11pg/mL) and/or the presence of funisitis/chorionic vasculitis) [7, 8] were significantly associated with an increased risk of hearing screening failure in very preterm neonates [9, 10], suggesting that infection/inflammation in utero, including fetal infection/ inflammation, may have a potentially deleterious effect on fetal auditory development.
(2) Thrombosis of fetal chorionic plate vessels, especially in the presence of severe fetal inflammatory response or funisitis
, is observed (Figure 15).
La principal causa de muerte fueron las infecciones ascendentes (corioamnionitis aguda, funisitis
aguda) seguidas del sindrome de transfusion feto-fetal.
(7) The study revealed a higher incidence of histologic chorioamnionitis and/or funisitis
when compared with those without an IUD (54.2% vs 14.7%, respectively; P<.001).
Anatomia patologica reporta: Sirenomelia tipo I con genitales externos ambiguos, ano imperforado, comunicacion interauricular, coartacion de aorta, neumonia, estenosis esofagica, diverticulo de Meckel, displasia renal izquierda, agenesia renal derecha, ambos ureteres y vejiga urinaria, agenesia de ovario izquierdo, bazo bilobulado, encefalitis y funisitis
. En este caso, corresponde al tipo I, con presencia de femur, tibia y perone bilateralmente.
, the inflammation of the umbilical cord, and vasculitis of fetal vessels in the fetoplacental unit can be regarded as histological markers for fetal inflammatory response.
MIAC and funisitis
have been associated with umbilical cord CRP-value , but our study had no intention to analyze postnatal cord samples.
Early delivery leads to problem of prematurity and on the other hand prolongation of pregnancy involves the risk of chorioamnionitis, funisitis
, dry labour, placental abruption in the mother and sepsis, respiratory distress syndrome, intraventricular haemorrhage in the newborn.