fumarase


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fumarase

 [fu´mah-rās]
an enzyme that catalyzes the interconversion of fumarate and malate.

fu·ma·rate hy·dra·tase

(fū'mă-rāt hī'dră-tās), [MIM*136850]
An enzyme catalyzing the reversible interconversion of fumarate and water to malate, a reaction of importance in the tricarboxylic acid cycle. A deficiency will lead to mental retardation.
Synonym(s): fumarase

fumarase

/fu·ma·rase/ (fu´mah-rās) an enzyme that catalyzes the interconversion of fumarate and malate.

fumarase

an enzyme that catalyzes the interconversion of fumarate and malate.
References in periodicals archive ?
The fumarase enzyme is released from cells when they are damaged from the outside.
If this functions, then we can in principle move directly to clinical practice with fumarase measurements," explains Per Mose Nielsen.
Fumarase deficiency is inherited in an autosomal recessive pattern.
Most newborns with fumarase deficiency display serious neurological anomalies including feeding difficulty, developmental retardation and hypotonia.
Enlarged brain ventricles and polyhydramniosis in the intrauterine follow-up of patients presenting with seizure, hypo or hypertonicity (opistotunus), microcephaly and growth retardation should suggest fumarase deficiency which is observed rarely.
Fumarase deficiency: a new cause of mitochondrial encephalomyopathy.
Lung Activity Filtered air CAPs Cu/ZnSOD (U/mg protein) 38 [+ or -] 7 38 [+ or -] 10 MnSOD (U/mg protein) 6 [+ or -] 3 10 [+ or -] 2 * Catalase (mU/mg protein) 43 [+ or -] 4 55 [+ or -] 5 * Fumarase (U/mg protein) 0.
MmcBC in Pelotomaculum thermopropionicum represents a novel group of prokaryotic fumarases.
Taylor, said the last time she checked with her daughter's doctor she was told there are fewer than 100 cases of fumarase deficiency worldwide.
She said most children who have fumarase deficiency succumb to the disease before their first birthday.